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End of covid crisis
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The objective of this research is to build a collection of non-invasive retinal imaging (OCT and OCTA) in order to investigate the incidence and impact of retinal damage in patients who have or have had COVID-19.
This monocentric study is aimed at 3 types of patients:
At the patient's inclusion, an ophthalmologic assessment will be performed including :
Fundus examination, optical coherence tomography (OCT) and optical coherence tomography angiography (OCTA) in all COVID-19 patients may detect retinal lesions. In addition, if a correlation is demonstrated between clinical and paraclinical parameters and between disease severity and retinal vascular damage in non-invasive imaging (OCT and OCTA), this would allow a better understanding of the pathophysiology of the disease, as well as factors that may influence disease severity and the mechanisms potentially responsible for the observed disorders.
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| Measure | Description | Time Frame |
|---|---|---|
| Retinal damage at inclusion after Covid-19 infection | Comparison of retinal damage in patients with patients with severe forms of Covid-19 versus patients with mild forms of the disease | Up to one week after inclusion |
| Measure | Description | Time Frame |
|---|---|---|
| Change of retinal vascular density at inclusion after Covid-19 infection | Comparison of retinal damage in patients with severe forms of Covid-19 versus patients with mild forms of the disease | Up to one week after inclusion |
| Impact of retinal vascular density changes on visual acuity at inclusion |
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Inclusion Criteria:
Exclusion Criteria:
- Refusal of patient participation
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Inpatients with COVID-19, patients who were hospitalised for COVID-19 and patients with COVID-19 who did not require hospitalisation
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| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Centre Hospitalier Intercommunal de Créteil | Créteil | IDF | 94000 | France |
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| ID | Term |
|---|---|
| D000086382 | COVID-19 |
| ID | Term |
|---|---|
| D011024 | Pneumonia, Viral |
| D011014 | Pneumonia |
| D012141 | Respiratory Tract Infections |
| D007239 | Infections |
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Severity and impact of retinal damage |
| Up to one week after inclusion |
| Presence of Retinal toxicity (atrophy) on multimodal retinal imagery | Correlation between the presence of changes in multimodal imaging (fundus autofluorescence, multicolor and OCTA) and the associated antiviral treatment for Covid-19. | Up to one week after inclusion |
| D014777 |
| Virus Diseases |
| D018352 | Coronavirus Infections |
| D003333 | Coronaviridae Infections |
| D030341 | Nidovirales Infections |
| D012327 | RNA Virus Infections |
| D008171 | Lung Diseases |
| D012140 | Respiratory Tract Diseases |