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| Name | Class |
|---|---|
| Palacky University | OTHER |
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The study examines changes in retinal oximetry in patients after COVID-19 disease. It aims to analyze and quantify possible retinal microvascular abnormalities that may result from possible post-inflammatory damage to the endothelium of the vessels associated with COVID-19 disease. Retinal vascular involvement may indicate similar changes in the vascular system in other organs.
The retinal blood vessels are the only blood vessels in the body that can be observed directly. Patients with COVID-19 pneumonia have been shown to have reduced macular vessel density in the foveal region. As a result, some layers of the retina atrophy, reducing oxygen consumption by the retina. Based on this, it is expected that patients after COVID-19 pneumonia, or after a more severe course of the disease, will have normal arterial retinal oxygen saturation but higher venous retinal oxygen saturation and lower arterio-venous difference than patients after mild disease.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| mild disease | asymptomatic or paucisymptomatic patients with laboratory-confirmed severe acute respiratory syndrome coronavirus 2 infection (SARS-CoV2-infection) who received outpatient care |
| |
| moderate disease | patients with laboratory-confirmed SARS-CoV2-infection and radiology-confirmed pneumonia who did not require extracorporeal membrane oxygenation |
| |
| severe disease | patients with laboratory-confirmed SARS-CoV2-infection and acute respiratory distress syndrome who required extracorporeal membrane oxygenation |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Central visual acuity | Diagnostic Test | Measurement of central visual acuity using ETDRS (Early Treatment Diabetic Retinopathy Study) optotypes or Snellen optotype chart. |
|
| Measure | Description | Time Frame |
|---|---|---|
| Successful performing of retinal oximetry images in 90% of enrolled patients. | 90% of captured fundus images of retinal oximetry are useful for subsequent analysis. | 3 months |
| Successful analysis of retinal oxygen saturation in 90% of enrolled patients. | The parameters analyzed by retinal oximetry are arterial retinal oxygen saturation (%), venous retinal oxygen saturation (%), arterio-venous difference (%), arteriolar and venular diameter (µm). | 3 months |
| Measure | Description | Time Frame |
|---|---|---|
| Successful performing of optical coherence tomography and angiography in 90% of enrolled patients. | 90% of captured images of optical coherence tomography and angiography are useful for subsequent analysis. | 3 months |
| Successful analysis of optical coherence tomography in 90% of enrolled patients. |
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Inclusion Criteria:
Exclusion Criteria:
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Groups will be recruited from patients examined at the Department of Respiratory Diseases and Tuberculosis of University Hospital Olomouc at the outpatient check-up.
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| Name | Affiliation | Role |
|---|---|---|
| Zuzana Schreiberova, MD | University Hospital Olomouc and Palacky University Olomouc | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Department of Ophthalmology, University Hospital Olomouc | Olomouc | Czechia |
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| ID | Term |
|---|---|
| D000086382 | COVID-19 |
| ID | Term |
|---|---|
| D011024 | Pneumonia, Viral |
| D011014 | Pneumonia |
| D012141 | Respiratory Tract Infections |
| D007239 | Infections |
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| ID | Term |
|---|---|
| D014065 | Tonometry, Ocular |
| D000072776 | Slit Lamp Microscopy |
| D041623 | Tomography, Optical Coherence |
| D000792 | Angiography |
| ID | Term |
|---|---|
| D003941 | Diagnostic Techniques, Ophthalmological |
| D019937 | Diagnostic Techniques and Procedures |
| D003933 | Diagnosis |
| D041622 | Tomography, Optical |
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| Intraocular pressure measurement | Diagnostic Test | Measurement of intraocular pressure using non-contact Canon TX-20P tonometer. |
|
| Slit lamp examination | Diagnostic Test | Slit lamp examination of the anterior and posterior segment of the eye after pharmacological dilation of the pupil using application of short-time mydriatics (1% tropicamide and 10% phenylephrine). |
|
| Retinal oximetry | Diagnostic Test | Performing of retinal oximetry with an Oxymap T1 instrument (Oxymap ehf.) paired with a Topcon TRC-50DX retinal camera. |
|
| Optical coherence tomography and angiography | Diagnostic Test | Performing of optical coherence tomography and angiography with the Spectralis Optical Coherence Tomography Plus (Heidelberg Engineering). |
|
The parameters analyzed by optical coherence tomography are central retinal thickness (µm), ganglion cell layer thickness (µm), retinal nerve fiber layer thickness (µm), choroid thickness (µm) in the macular region and optic nerve head retinal nerve fiber layer thickness (µm). |
| 3 months |
| Successful analysis of optical coherence tomography angiography in 90% of enrolled patients. | The parameter analyzed by optical coherence tomography angiography is the size of foveal avascular zone (µm2). | 3 months |
| D014777 |
| Virus Diseases |
| D018352 | Coronavirus Infections |
| D003333 | Coronaviridae Infections |
| D030341 | Nidovirales Infections |
| D012327 | RNA Virus Infections |
| D008171 | Lung Diseases |
| D012140 | Respiratory Tract Diseases |
| D061848 | Optical Imaging |
| D003952 | Diagnostic Imaging |
| D014054 | Tomography |
| D008919 | Investigative Techniques |
| D011859 | Radiography |
| D003935 | Diagnostic Techniques, Cardiovascular |