The Effect of Perioperative Lidocaine Infusion on Neutrophil Extracellular Trapping

The Effect of Perioperative Lidocaine Intravenous Infusion on Neutrophil Extracellular Trapping After Surgery for Stomach Cancer

To investigate the effect of perioperative lidocaine infusion on the neutrophil extracellular trapping after minimally invasive surgery for stomach cancer

To investigate the effect of perioperative lidocaine infusion on the neutrophil extracellular trapping, especially citrullinated histone3, neutrophil elastase, myeloperoxidase

Inclusion Criteria:

• diagnosis of stomach cancer
• ASA class I-III
• no metastatic disease

Exclusion Criteria:

• hepatic, renal disease
• chronic inflammatory disease, eg. rheumatoid arthritis
• steroid or anti-inflammatory drug medication
• allergies to study drugs
• neuropsychiatric disease
• refusal of participation
• breast feeding or pregnancy
• weight < 40 kg