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This study will be done to investigate perioperative lidocaine infusion on neutrophil extracellular trapping in the patients undergoing the robot-assisted prostatectomy.
Neutrophil extracellular trapping by analyzing the meyloperoxidase, neutrophil elastase, citrullinated histone3
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| lidocaine group | Experimental | The study group receives perioperative lidocaine infusion with general anesthesia for robot-assisted prostatectomy |
|
| control group | Placebo Comparator | The control group receives normal saline infusion with with general anesthesia for robot-assisted prostatectomy |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| lidocaine group | Drug | lidocaine 1.5 mg/kg bolus (infused over 10 min) followed by 2.0 mg/kg/h during operation and 1.0 mg/kg/h during postoperative 24 hours (no more than 120 mg/h) |
| Measure | Description | Time Frame |
|---|---|---|
| Concentration of citrullinated histone3 | This will be obtained using ELISA. | 24 hours after surgery |
| Measure | Description | Time Frame |
|---|---|---|
| Concentration of meyloperoxidase | This will be obtained using ELISA. | 24 hours after surgery |
| Concentration of neutrophil elastase | This will be obtained using ELISA. |
| Measure | Description | Time Frame |
|---|---|---|
| the severity of postoperative pain using NRS | This will be measured using NRS (numeric rating scale; 0=no pain, 10=the worst pain) | during postoperative 24 hours |
Inclusion Criteria:
Exclusion Criteria:
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| Name | Affiliation | Role |
|---|---|---|
| Young Eun Moon, MD, PhD | Seoul St. Mary's Hospital | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Seoul St.Mary's Hospital | Seoul | Seocho-gu | 07651 | South Korea |
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| ID | Term |
|---|---|
| D014571 | Urologic Neoplasms |
| ID | Term |
|---|---|
| D014565 | Urogenital Neoplasms |
| D009371 | Neoplasms by Site |
| D009369 | Neoplasms |
| D052776 | Female Urogenital Diseases |
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| ID | Term |
|---|---|
| D008012 | Lidocaine |
| D035061 | Control Groups |
| D000077330 | Saline Solution |
| ID | Term |
|---|---|
| D000083 | Acetanilides |
| D000813 | Anilides |
| D000577 | Amides |
| D009930 | Organic Chemicals |
| D000814 |
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|
| control group | Drug | normal saline 0.15 ml bolus followed by 0.2 ml/kg/hr during operation and 0.1 ml/kg/hr during postoperative 24 hours |
|
|
| 24 hours after surgery |
| D005261 |
| Female Urogenital Diseases and Pregnancy Complications |
| D000091642 | Urogenital Diseases |
| D052801 | Male Urogenital Diseases |
| D014570 | Urologic Diseases |
| Aniline Compounds |
| D000588 | Amines |
| D015340 | Epidemiologic Research Design |
| D004812 | Epidemiologic Methods |
| D008919 | Investigative Techniques |
| D012107 | Research Design |
| D008722 | Methods |
| D000077324 | Crystalloid Solutions |
| D007552 | Isotonic Solutions |
| D012996 | Solutions |
| D004364 | Pharmaceutical Preparations |