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The purpose of this study is to determine whether intravenous lidocaine increase the tolerability of early oral feeding after laparoscopic colorectal surgery in patients with colorectal cancer.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Lidocaine | Experimental |
| |
| Placebo | Placebo Comparator |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Lidocaine | Drug | Lidocaine 1mg/kg(loading dose, just before skin incision) and lidocaine(in normal saline, total 240cc) 1mg/kg/hr with ketorolac 90mg for 24hrs. |
|
| Measure | Description | Time Frame |
|---|---|---|
| Prevalence of postoperative nausea and vomiting. | Intolerance to early postoperative oral feeding is defined as the patient's having either nausea or vomiting, requiring that the patient be non-per oral status. | From day of surgery to sixth postoperative day. |
| Measure | Description | Time Frame |
|---|---|---|
| Time to first flatus. | From day of surgery to sixth postoperative day. | |
| Time to first passage of stool. | From day of surgery to sixth postoperative day. | |
| Degree of postoperative pain. |
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Inclusion Criteria:
Exclusion Criteria:
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| Name | Affiliation | Role |
|---|---|---|
| Hyung Ook Kim, M.D | Kangbuk Samsung Hospital | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Hyung Ook Kim | Seoul | 110-746 | South Korea |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 24612414 | Derived | Kim HO, Lee SR, Choi WJ, Kim H. Early oral feeding following laparoscopic colorectal cancer surgery. ANZ J Surg. 2014 Jul-Aug;84(7-8):539-44. doi: 10.1111/ans.12550. Epub 2014 Feb 24. |
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| ID | Term |
|---|---|
| D015179 | Colorectal Neoplasms |
| ID | Term |
|---|---|
| D007414 | Intestinal Neoplasms |
| D005770 | Gastrointestinal Neoplasms |
| D004067 | Digestive System Neoplasms |
| D009371 | Neoplasms by Site |
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| ID | Term |
|---|---|
| D008012 | Lidocaine |
| D000077330 | Saline Solution |
| ID | Term |
|---|---|
| D000083 | Acetanilides |
| D000813 | Anilides |
| D000577 | Amides |
| D009930 | Organic Chemicals |
| D000814 |
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| Normal saline | Drug | Normal saline 5cc(loading dose, just before skin incision) and normal saline 240cc with ketorolac 90mg for 24hrs. |
|
| From day of surgery to sixth postoperative day. |
| Postoperative opioid consumption. | From day of surgery to sixth postoperative day. |
| Time to tolerance of regular diet | From day of surgery to sixth postoperative day. |
| Postoperative complications | From day of surgery to thirtieth postoperative day. |
| Duration of postoperative hospital stay. | From day of surgery until discharge, an expected average of nine days. |
| D009369 | Neoplasms |
| D004066 | Digestive System Diseases |
| D005767 | Gastrointestinal Diseases |
| D003108 | Colonic Diseases |
| D007410 | Intestinal Diseases |
| D012002 | Rectal Diseases |
| Aniline Compounds |
| D000588 | Amines |
| D000077324 | Crystalloid Solutions |
| D007552 | Isotonic Solutions |
| D012996 | Solutions |
| D004364 | Pharmaceutical Preparations |