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Prospectively enrolled retrospective chart review and Liver Transplant database review to determine the modifiable and nonmodifiable risk factors specifically relating to Living Donor Liver Transplants. To observe the impact of age and BMI on graft outcomes and whether they impact the intraoperative management, post-operative length of stay, and complications.
There has been a great deal of research into the characteristics of the donor for organ transplant, with older donors and those with more comorbidities having worse function once the organ is implanted. There has not been a great deal of research in the United States about the recipient's characteristic including age and BMI and the effects on donor organ function. With increasingly expanded criteria for organ recipients especially in the field of living donor organs the investigators plan to show the impact of older age and increased BMI on newly transplanted organs.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Living Donor Liver Transplant Recipient | Patients who have received a living donor liver transplant. |
| |
| Deceased Donor Liver Transplant Recipient | Patients who have received either a Deceased by Circulatory Death or Deceased by Brain Death Liver Transplant |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Cadaveric | Procedure | Cadaveric Organ Transplant |
| |
| Measure | Description | Time Frame |
|---|---|---|
| Graft Function 30 day | How well does the organ function | 30 day |
| Mortality | Mortality at 1 year | 1 year |
| Graft Survival 1 year | Survival of Organ at 1 year | 1 year |
| Measure | Description | Time Frame |
|---|---|---|
| Perioperative Complications | Any complications in the perioperative period | 30 day |
| Length of Stay- Total and ICU | How long after surgery before patient is discharged from ICU and from Hospital |
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Inclusion Criteria:
Exclusion Criteria:
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Patients with end-stage liver disease, cirrhosis, or cancer requiring a liver transplant.
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| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| UPMC Montefiore | Pittsburgh | Pennsylvania | 15207 | United States |
No current plans
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| ID | Term |
|---|---|
| D011183 | Postoperative Complications |
| ID | Term |
|---|---|
| D010335 | Pathologic Processes |
| D013568 | Pathological Conditions, Signs and Symptoms |
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| Living Donor |
| Procedure |
Living Donor Organ Transplant |
|
| Up to 6 months |
| Duration of Intubation/Ventilation | Time from Surgery End to Extubation or no longer requiring ventilatory support | Up to 6 months |
| Postoperative Complications | Complications in the postoperative period- Renal, Infectious Disease, Pulmonary, Cardiac, Transplant related, Reintubation, Reoperation | Up to 6 months |
| Blood Transfusion | Amount of blood transfusion required intraoperatively | Up to 2 days |
| Vasoactive Medication | Amount and Type of Vasoactive Medication used at procedure end | Up to 2 days |