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Perioperative bleeding is the most common complication related to transurethral resection of prostate, the aim of the study is to compare the effect of pre-operative use of finasteride versus Cyproterone acetate on blood loss with mono polar TURP
This prospective randomized controlled study to compare the effect of pre-operative use of finasteride versus Cyproterone acetate on blood loss with mono polar TURP
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| cyproterone acetate | Active Comparator | 20 patients received cyproterone acetate 50 mg twice per day for two weeks before TURP |
|
| finasteride group | Active Comparator | 20 patients received finasteride 5 mg once per day for two weeks before TURP |
|
| control group | Placebo Comparator | 20 patients received no treatment before TURP |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| cyproterone acetate | Drug | two weeks Cyproterone acetate administration before TURP |
| |
| Measure | Description | Time Frame |
|---|---|---|
| post operative Hb | measuring serum haemoglobin level at first post operative | 24 hour post operative |
| post operative Hcv | measuring serum haematocrit value at first post operative | 24 hour post operative |
| operative duration | assessment of the duration of the operation | immediately after surgery |
| microvascular density(MVD) | assesment of MVD of the prostate by histological examination using high power field microscope | 2 weeks after drug intake |
| intraoperative blood loss | assessment of intraoperative blood loss during TURP | immediately after surgery |
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Inclusion Criteria:
Exclusion Criteria:
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| Name | Affiliation | Role |
|---|---|---|
| shabieb ahmed, Ph.D | faculty of medicine, Benha university | Study Director |
| abdallah fathy, Ph.D | faculty of medicine, Benha university | Study Director |
| mohamed hefnawy, Ph.D | faculty of medicine, Benha university | Study Chair |
| adel al falah, Ph.D | faculty of medicine, Benha university | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Benha University | Banhā | Qalyubia Governorate | 15311 | Egypt |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 28753756 | Background | Treharne C, Crowe L, Booth D, Ihara Z. Economic Value of the Transurethral Resection in Saline System for Treatment of Benign Prostatic Hyperplasia in England and Wales: Systematic Review, Meta-analysis, and Cost-Consequence Model. Eur Urol Focus. 2018 Mar;4(2):270-279. doi: 10.1016/j.euf.2016.03.002. Epub 2016 Mar 23. | |
| 29538495 |
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| ID | Term |
|---|---|
| D011470 | Prostatic Hyperplasia |
| ID | Term |
|---|---|
| D011469 | Prostatic Diseases |
| D005832 | Genital Diseases, Male |
| D000091662 | Genital Diseases |
| D000091642 | Urogenital Diseases |
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| ID | Term |
|---|---|
| D017373 | Cyproterone Acetate |
| D018120 | Finasteride |
| ID | Term |
|---|---|
| D003534 | Cyproterone |
| D011245 | Pregnadienes |
| D011278 | Pregnanes |
| D013256 | Steroids |
| D000072473 |
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| finasteride |
| Drug |
two weeks finasteride administration before TURP |
|
| no treatment received | Drug | no treatment received before TURP |
|
| Yang TY, Chen M, Lin WR, Li CY, Tsai WK, Chiu AW, Ko MC. Preoperative treatment with 5alpha-reductase inhibitors and the risk of hemorrhagic events in patients undergoing transurethral resection of the prostate - A population-based cohort study. Clinics (Sao Paulo). 2018 Mar 12;73:e264. doi: 10.6061/clinics/2018/e264. |
| 26975954 | Background | Khwaja MA, Nawaz G, Muhammad S, Jamil MI, Faisal M, Akhter S. The Effect of Two Weeks Preoperative Finasteride Therapy in Reducing Prostate Vascularity. J Coll Physicians Surg Pak. 2016 Mar;26(3):213-5. |
| 25789687 | Background | Tian HL, Zhao CX, Wu HY, Xu ZX, Wei LS, Zhao RT, Jin DL. Finasteride reduces microvessel density and expression of vascular endothelial growth factor in renal tissue of diabetic rats. Am J Med Sci. 2015 Jun;349(6):516-20. doi: 10.1097/MAJ.0000000000000451. |
| D052801 |
| Male Urogenital Diseases |
| Fused-Ring Compounds |
| D011083 | Polycyclic Compounds |
| D013258 | Steroids, Chlorinated |
| D000736 | Androstenes |
| D000731 | Androstanes |
| D001378 | Azasteroids |
| D013260 | Steroids, Heterocyclic |