Spinal Versus General Anesthesia on Coagulation and Fibrinolysis During Transurethral Resection of the Prostate | NCT07734233

NCT07734233

Overview

NCT ID: NCT07734233
Lead Sponsor: Haseki Training and Research HospitalOTHER
Official Title: Effects of Spinal Versus General Anesthesia on Coagulation and Fibrinolysis in Patients Undergoing Transurethral Resection of the Prostate: A Prospective Randomized Study
Brief Summary: This prospective randomized clinical trial aims to compare the effects of spinal and general anesthesia on perioperative coagulation and fibrinolysis in patients undergoing elective transurethral resection of the prostate (TURP). Blood samples are collected before surgery and at 1 and 24 hours postoperatively to evaluate coagulation and fibrinolytic parameters. The study also assesses perioperative hemodynamic events and postoperative complications.
Conditions: Benign Prostatic Hyperplasia
Transurethral Resection of the Prostate (TURP)

Ages Eligible for Study: Adult (18-64)Older Adult (65+)
Sexes Eligible for Study: Male
Accepts Healthy Volunteers?: No
Eligibility Criteria: Inclusion Criteria:

Male patients

Age ≥18 years

Scheduled for elective bipolar transurethral resection of the prostate

ASA physical status I-II

Ability to provide written informed consent

Exclusion Criteria:

History of deep vein thrombosis or pulmonary embolism

Known inherited or acquired coagulation disorder

Severe hepatic insufficiency

Severe renal insufficiency

Use of anticoagulants, antiplatelet drugs, or NSAIDs within 10 days before surgery

Platelet count <100 × 10⁹/L

INR >1.5

aPTT >47 seconds

Contraindications to spinal anesthesia

Prostate malignancy

ASA physical status III or higher

Refusal to participate