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It is a prospective, monocentric, interventional study on spontaneous vaginal clearance of Mycoplasma genitalium.
The main objective is to evaluate the spontaneous vaginal clearance of M. genitalium in patients coming to perform a voluntary termination of pregnancy at the University Hospital of Bordeaux at 9 weeks after a vaginal sample positive for M. genitalium
Mycoplasma genitalium is a bacterium that colonizes female genital tract and can be responsible for sexually transmitted infection . M. genitalium can cause cervicitis and more rarely high genital infections.
In the vast majority of cases, presence of M. genitalium is not accompanied by any symptoms and women do not develop disease. Natural history of M. genitalium infection is not well documented. Some studies have shown a natural clearance of infection in women. The published work mainly concerns patients at very high risk of sexually transmitted disease, but we do not have French data.
We propose to study the natural clearance of M. genitalium infection in patients consulting at the Orthogeny Centre of the University Hospital of Bordeaux. Results of this work will allow us to have a better knowledge of the natural history of M. genitalium infection.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Vaginal self-sampling | Experimental | Vaginal self-sampling performed by the patient at the follow-up visit at 3 weeks and remote follow-up at 9 weeks. |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Vaginal self-sampling | Other | Vaginal self-sampling performed by the patient at the follow-up visit at 3 weeks and remote follow-up at 9 weeks. |
|
| Measure | Description | Time Frame |
|---|---|---|
| clearance at week 3 | The clearance will be defined by a negative PCR test for M. genitalium in the vaginal sample taken at week 3. | Week 3 |
| Measure | Description | Time Frame |
|---|---|---|
| clearance at week 9 | The clearance defined by a negative PCR test for M. genitalium in the vaginal sample taken at week 9. | Week 9 |
| Prevalence of N. gonorrhoeae infections | Prevalence of infections with N. gonorrhoeae calculated by making the ratio between the number of patients with a positive vaginal swab for N. gonorrhoeae compared to the total number of patients tested. |
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Inclusion Criteria:
Exclusion criteria:
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| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| CHU Bordeaux | Bordeaux | France |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 41502158 | Derived | Berdoyes M, Bebear C, Roy CL, Balcon C, Hocke C, Baita D, Peuchant O. Spontaneous Clearance of Vaginal Mycoplasma genitalium in Women Undergoing Pregnancy Termination: A Prospective Cohort Study. BJOG. 2026 Apr;133(5):1074-1082. doi: 10.1111/1471-0528.70151. Epub 2026 Jan 7. |
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Vaginal self-sampling performed by the patient at the follow-up visit at 3 weeks and remote follow-up at 9 weeks
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| Week 3, Week 9 |
| Prevalence of C. trachomatis infections | Prevalence of infections with C. trachomatis calculated by making the ratio between the number of patients with a positive vaginal swab for C. trachomatis compared to the total number of patients tested. | Week 3, Week 9 |
| Prevalence of M. genitalium infections | Prevalence of infections with M. genitalium, calculated by making the ratio between the number of patients with a positive vaginal swab for M. genitalium compared to the total number of patients tested. | Week 3, Week 9 |
| patient's sex life | patient's sex life, assessed by a self-questionnaire | Week 3, Week 9 |