Wet-suction Versus Slow-pull for EUS-FNB of Solid Lesions

Wet-suction Versus Slow-pull Technique for Endoscopic Ultrasound-guided Fine-needle Biopsy of Solid Lesions: a Multicentric Randomized Controlled Trial

A randomized cross-over study investigating the impact of two different suction techniques on histological yield and sample quality of specimens collected by endoscopic ultrasound biopsy from solid lesions using histology needles.

Inclusion Criteria:

• Solid pancreatic lesions 3 1cm
• Peri-GI tract lymph nodes 3 1cm
• Peri-GI tract masses
• Lesions of the GI wall
• Signed informed consent

Exclusion Criteria:

• Pancreatic cystic lesions (more than 50% of the volume)
• Diameter of lesion ≤ 1 cm
• Lesion not seen at EUS
• Pregnancy
• Coagulopathy (platelet count <50.000/mm3 and/or international normalized ratio >1.5);
• Severe cardiorespiratory dysfunction precluding endoscopy;
• Failure to provide informed consent