Comparision of EUS-FNB Techniques for Diagnose of Solid Pancreatic Lesions

Official Title: Dry Suction Technique Versus Wet Suction Technique of Endoscopic Ultrasound-Guided Fine-needle Biopsy for Diagnosis of Solid Pancreatic Lesions: A Randomized Controlled Non-Inferiority Trial

Studies have shown that the wet-suction technique in EUS-FNA generates better histological diagnostic accuracy and specimen quality than the dry-suction technique. However, studies on wet suction on the diagnostic accuracy of EUS-FNB is small and the conclusions are controversial. Besides, the optional numeber of passes for EUS-FNB has not been determined.

The investigators aimed to design a large multicenter randomized trial to compare the diagnostic accuracy and the optimal number of passes required for EUS-FNB in solid pancreatic lesions using 22G Franseen under wet aspiration versus standard aspiration.

Inclusion Criteria:

• Age from 18 to 75 years;
• Patients with solid pancreatic lesions evidenced by CT or MRI who do not have a histopathological diagnosis.
• Plan to receive EUS-FNB.
• Able to obtained informed consent.

Exclusion Criteria:

• Had expected difficulty of endoscope insertion
• That no lesion in the pancreas is identified by EUS
• Use of anticoagulants/antiplatelet drugs that cannot be discontinued.
• Had a bleeding tendency, defined as an international normalized ratio of the prothrombin time >1.5 or a platelet count <50,000 cells/mL
• Other medical conditions that render the patient an unsuitable candidate for EUS-FNB.
• Vulnerable groups such as pregnant women or patients with mental disorders;
• Patients unable to understand and/or read the consent form.