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This investigations aims to investigate whether supplementation with antioxidant vitamins (vitamin C and vitamin E) can influence, enhancing or blocking, the hypertrophic adaptations caused by strength training in sedentary subjects.
A randomized, double-blind, placebo-control controlled trial will be conducted. In a previous session volunteers will be interviewed to determine if they meet the inclusion criteria. Will be done two weeks of flushing out other types of supplementation and strenuous physical exercise, along with familiarization with the strength training program and performance tests to be carried out during the rehearsal. Subsequently, it will be a week without exercising to start with the experimental designs. From the start of the trial, participants should avoid physical exercise. strenuous outside the training protocol and if usual, they will only be able to perform one resistance training session per week. Participants should avoid ingesting of foods that contain high amounts of antioxidant compounds: more than two juices of fruits, more than four cups of coffee or tea. Juices with high antioxidant content should be avoided. Alcoholic beverages should also be avoided.
All participants will ingest the supplementation between 1-3 hours before training, the days of rest in the mornings.
All participants will perform a 12-week strength training protocol. The training session performed in the sharp design will be the first training session in chronic design. Being the baseline (E0) and post-exercise (E1) assessment performed in G1, G2 and G3 also the first evaluation corresponding to the chronic design.
In the middle of the supplementation period (week 6) and at the end, two new evaluations (week 12). Baseline evaluations will be performed prior to an exercise session of week 6 (E2) and at the last exercise session (E3) of the following parameters: performance physique, body composition, micronutrient analysis, muscle ultrasound. I also know conduct post-exercise physical performance assessments Figure 2.
The strength training protocol will be carried out 4 days a week at the facilities sports of the European University. The sessions will be planned by a professional from the Sciences of Physical Activity and Sports. Sessions will be tracked through a diary.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Supplementation group | Active Comparator | Antioxidant vitamins (Vitamin C (1000 mg) + Vitamine E (235 mg)) |
|
| Placebo group | Placebo Comparator | Placebo supplementation with the same aspect as supplementation |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Vitamin C and vitamin E | Dietary Supplement | 1000 mg 235 mg |
|
| Measure | Description | Time Frame |
|---|---|---|
| DEXA | Evaluation of muscle mass with dual energy X-ray absorptiometry | Week 0 |
| DEXA | Evaluation of muscle mass with dual energy X-ray absorptiometry | Week 10 |
| Anthropometry | Evaluation of muscle mass by a ISAK 1 level anthropometrist | Week 0 |
| Anthropometry | Evaluation of muscle mass by a ISAK 1 level anthropometrist | Week 5 |
| Anthropometry | Evaluation of muscle mass by a ISAK 1 level anthropometrist | Week 10 |
| Bioimpedance | Evaluation of muscle mass with an Inbody | Week 0 |
| Bioimpedance | Evaluation of muscle mass with an Inbody | Week 5 |
| Bioimpedance | Evaluation of muscle mass with an Inbody | Week10 |
| DOMS | Delayed onset muscle soreness evaluated with visual analoguic scale (0 no pain- 10 maximal pain) |
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Inclusion Criteria:
Exclusion Criteria:
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| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Universidad Europea de Madrid | Madrid | 28011 | Spain |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 31970196 | Background | Dutra MT, Martins WR, Ribeiro ALA, Bottaro M. The Effects of Strength Training Combined with Vitamin C and E Supplementation on Skeletal Muscle Mass and Strength: A Systematic Review and Meta-Analysis. J Sports Med (Hindawi Publ Corp). 2020 Jan 8;2020:3505209. doi: 10.1155/2020/3505209. eCollection 2020. | |
| 29939770 | Result |
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| ID | Term |
|---|---|
| D006984 | Hypertrophy |
| ID | Term |
|---|---|
| D020763 | Pathological Conditions, Anatomical |
| D013568 | Pathological Conditions, Signs and Symptoms |
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| ID | Term |
|---|---|
| D001205 | Ascorbic Acid |
| D014810 | Vitamin E |
| D024505 | Tocopherols |
| ID | Term |
|---|---|
| D013400 | Sugar Acids |
| D000144 | Acids, Acyclic |
| D002264 | Carboxylic Acids |
| D009930 | Organic Chemicals |
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A randomized, double-blind, placebo-control, parallel controlled trial will be conducted.
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The provider will produce the supplementation and the placebo with the same aspect, marked with numbers
| Placebo | Dietary Supplement | Placebo |
|
| Week 0 |
| DOMS | Delayed onset muscle soreness evaluated with visual analoguic scale (0 no pain- 10 maximal pain) | Week 5 |
| DOMS | Delayed onset muscle soreness evaluated with visual analoguic scale (0 no pain- 10 maximal pain) | Week 10 |
| Manual dinamometry | Handgrip | Week 0 |
| Manual dinamometry | Handgrip | Week 5 |
| Leg dinamometry | Dinamometer | Week 0 |
| Leg dinamometry | Dinamometer | Week 5 |
| Leg dinamometry | Dinamometer | Week 10 |
| RPE | 10-point scale (no exertion 0- maximal effort 10) | Week 0 |
| RPE | 10-point scale (no exertion 0- maximal effort 10) | Week 5 |
| RPE | 10-point scale (no exertion 0- maximal effort 10) | Week 10 |
| 1 RM | Bench press and squats | Week 0 |
| 1 RM | Bench press and squats | Week 5 |
| 1 RM | Bench press and squats | Week 10 |
| Parameters determined by ENCODER | Bench press and squats | Week 0 |
| Parameters determined by ENCODER | Bench press and squats | Week 5 |
| Parameters determined by ENCODER | Bench press and squats | Week 10 |
| Dutra MT, Alex S, Mota MR, Sales NB, Brown LE, Bottaro M. Effect of strength training combined with antioxidant supplementation on muscular performance. Appl Physiol Nutr Metab. 2018 Aug;43(8):775-781. doi: 10.1139/apnm-2017-0866. Epub 2018 Jun 25. |
| D006880 |
| Hydroxy Acids |
| D002241 | Carbohydrates |
| D001578 | Benzopyrans |
| D011714 | Pyrans |
| D006573 | Heterocyclic Compounds, 1-Ring |
| D006571 | Heterocyclic Compounds |
| D006574 | Heterocyclic Compounds, 2-Ring |
| D000072471 | Heterocyclic Compounds, Fused-Ring |