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This crossover study is designed to compare the rates of gastric emptying between two diagnostic radioactive meals using the gold-standard egg-white sandwich meal and Abbott Vital®. Healthy participants will be recruited and randomly assigned into either groups of Abbott Vital® and gold-standard egg-white sandwich group. The measurements will be performed over a 4-hour period using a gamma camera, and estimated gastric emptying rates will be calculated using established algorithms.
The gold-standard egg-white sandwich is quite difficult and complicated for staffs to prepare because the food needs to be cooked first and it will take time to prepare. Besides, the egg-white sandwich is not suitable for those with allergies to egg and bread and also to vegetarian patients. This gold-standard meal is also not a common meal for Asian people so some of the people may not tolerate with the meal. The aim of this study is to determine whether Abbott Vital® is as reliable as the gold-standard egg-white sandwich by comparing the gastric meal retention of both meals.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Group 1 | Egg-white sandwich is added with 1 mCi Tc-99m sodium phytate, then Abbott Vital® added with 1 mCi Tc-99m sodium phytate |
| |
| Group 2 | Abbott Vital® is added with 1 mCi Tc-99m sodium phytate, then egg-white sandwich added with 1 mCi Tc-99m sodium phytate |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Egg-white sandwich | Radiation | 1 mCi of Tc-99m sodium phytate is added into the egg-white sandwich |
|
| Measure | Description | Time Frame |
|---|---|---|
| Change of gastric emptying rates | Percentage of gastric meal retention (GMR; %) | 4 hours (0 hour, 1/2-hour, 1-hour, 2-hour, 3-hour, 4-hour) |
| Measure | Description | Time Frame |
|---|---|---|
| Half-emptying time and slope | Time required by the stomach to empty 50% of the ingested meal (T1/2; minutes) | T1/2 |
| Symptoms and satiety/satiation | Intensity of perceived symptom and satiety/satiation based on Visual Analogue Scale (VAS) |
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Inclusion Criteria:
Exclusion Criteria:
15 males and 15 females
Reference population is staff and students who are within the campus of Universiti Sains Malaysia and Hospital Universiti Sains Malaysia
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| Name | Affiliation | Role |
|---|---|---|
| Izleen Laili B Ibrahim | Universiti Sains Malaysia | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Hospital Universiti Sains Malaysia | Kota Bharu | 16150 | Malaysia |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
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| 30285398 |
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| Abbott Vital® | Radiation | 1 mCi of Tc-99m sodium phytate is added into the Abbott Vital® |
|
| 4 hours (0 hour, 1/2-hour, 1-hour, 2-hour, 3-hour, 4-hour) |
| Background |
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