The study evaluated the effect of local application of simvastatin around immediate implant on the amount of gap fill, ridge dimensional alterations and bone density in humans.

Inclusion Criteria:

• Patients between 20 and 50 years old
• requiring the extraction of 2 non-restorable maxillary canine or premolar on each side of the arch
• following extraction, the crestal bone had to be located 3 mm apical to the free gingival margin
• at least 3 mm of bone beyond the root apex was required to guarantee implant primary stability

Exclusion Criteria:

• unstable systemic diseases precluding surgical procedures
• compromised general health conditions that would impair bone healing including present history of bone irradiation, patient on bisphosphonates therapy, antitumor chemotherapy
• pregnancy
• compromised healing conditions e.g. uncontrolled diabetes mellitus