Simvastatin Around Immediate Implant

Restoration of Immediate Peri-implant Defect by Simvastatin: a Controlled Clinical and Cone Beam Computed Tomography Study

The study evaluated the effect of local application of simvastatin around immediate implant on the amount of gap fill, ridge dimensional alterations and bone density in humans.

Inclusion Criteria:

• Patients between 20 and 50 years old
• requiring the extraction of 2 non-restorable maxillary canine or premolar on each side of the arch
• following extraction, the crestal bone had to be located 3 mm apical to the free gingival margin
• at least 3 mm of bone beyond the root apex was required to guarantee implant primary stability

Exclusion Criteria:

• unstable systemic diseases precluding surgical procedures
• compromised general health conditions that would impair bone healing including present history of bone irradiation, patient on bisphosphonates therapy, antitumor chemotherapy
• pregnancy
• compromised healing conditions e.g. uncontrolled diabetes mellitus