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Background: In recent years, there has been a rise in the use of immediate loading protocols; however, the complex anatomy of the posterior maxilla presents challenges. Currently, there is a lack of comparative studies assessing the effects of hyaluronic acid and atorvastatin gel on enhancing bone density in this region in conjunction with immediate loading. This study aimed to compare the effect of topical application of atorvastatin gel versus hyaluronic acid around immediately loaded dental implant that replacing missed maxillary posterior teeth.
Patients and methods: twenty one patients were chosen from the Outpatient Clinic in the Oral and Maxillofacial Surgery Department, Faculty of Dentistry, Mansoura University seeking implant placement. Patients were divided randomly and equally into three groups: group I (control group): 7 patients received implants without coating by any materials. Group II [Hyaluronic acid (HA) group]: 7 patients received implants coated with HA gel .Group III [atorvastatin (ATV) group]: 7 patients received implants coated with ATV gel. Clinical evaluation of implant stability was performed at the time of implant insertion and after 3 and 6 months postoperative. Also, peri-implant pocket depth (PPD) and modified sulcus bleeding index (mSBI) were evaluated. Radiographical evaluation of bone density (BD) was performed immediately and after 6 months postoperatively of implant loading using CBCT. All clinical and radiographic data were subjected to statistical analysis.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| hyaluronic acid | Experimental | [Hyaluronic acid (HA) group]: 7 patients received implants coated with HA gel . |
|
| atorvastatin | Experimental | [atorvastatin (ATV) group]: 7 patients received implants coated with ATV gel |
|
| control | Experimental | group I (control group): 7 patients received implants without coating by any materials. |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| implant surgery | Procedure | surgery |
|
| Measure | Description | Time Frame |
|---|---|---|
| clinical evaluation | Clinical evaluation of implant stability was performed at the time of implant insertion and after 3 and 6 months postoperative. | 6 months |
| clinical evaluation | Clinical evaluation of implant stability was performed at the time of implant insertion and after 3 and 6 months postoperative. Also, peri-implant pocket depth (PPD) and modified sulcus bleeding index (mSBI) were evaluated. | 6 months |
| clinical evaluation | peri-implant pocket depth (PPD) around the implant at 3 months and 6 months after loading | 6 months |
| Measure | Description | Time Frame |
|---|---|---|
| radiographic evaluation | Radiographical evaluation of bone density (BD) was performed immediately and after 6 months postoperatively of implant loading using CBCT | 6 months |
| clinical evaluation |
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Inclusion Criteria:
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Inclusion criteria:
Exclusion Criteria:
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| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Amira Attia | Al Mansurah | Egypt |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 41928180 | Derived | Attia AAMM, Eissa SM, Ellayeh M, Marzook HAM. Effect of topical application of atorvastatin gel versus hyaluronic acid on immediate loading dental implant in posterior maxilla: a randomized controlled trial. BMC Oral Health. 2026 Apr 2;26(1):638. doi: 10.1186/s12903-026-08081-4. |
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modified sulcus bleeding index (mSBI) were evaluated at 3 months and 6 months after loading
| 6 months |