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This is an intervention study aiming to test the effectiveness of a vegan diet, My Plate with low purine choices, and amla fruits on uric acid and other cardiometabolic risk factors in individuals with high serum uric acid levels.
Ninety-two participants with hyperuricemia will be randomly assigned to one of these 4 diet interventions: (1) vegan, (2) vegan with amla fruits, (3) my plate-low purine, (4) my plate-low purine with amla fruits. During the 3 months intervention phase, participants will attend group lessons and individual nutrition counseling sessions to assist adherence to the diet. At baseline, end of 3 months, and 1 year, participants will be measured on uric acid and other cardiometabolic risk factors, and some nutritional markers. Amla fruits powder, and some foods encouraged in each dietary arm will be provided to enhance adherence during the 3 months intervention phase.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Healthy Vegan Diet | Experimental | Education on healthy vegan diet |
|
| Healthy Vegan Diet with Amla fruits | Experimental | Education on healthy vegan diet, 3g of powdered amla fruits per day |
|
| My Plate - Low Purine | Active Comparator | Education on "My Plate" diet with emphasis on choosing low purine protein options. |
|
| My Plate - Low Purine with Amla Fruits. | Experimental | Education on "My Plate" diet with emphasis on choosing low purine protein options and with an addition of 3g of amla powder per day. |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Healthy vegan diet | Other | Participants will attend group lessons and individual nutrition counseling to help them adopt a healthy vegan diet. |
|
| Measure | Description | Time Frame |
|---|---|---|
| Uric acid | Serum uric acid | 3 months |
| Measure | Description | Time Frame |
|---|---|---|
| Body mass index | body mass index calculated from height and weight | 3 months |
| Glucose metabolism | fasting glucose | 3 months |
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Inclusion Criteria:
Exclusion Criteria:
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| Name | Affiliation | Role |
|---|---|---|
| Tina Hsueh-Ting Chiu, PhD | Fu-Jen Catholic University, Department of Nutritional Science | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Department of Nutritional Science, Fu-Jen Catholic University | New Taipei City | 24205 | Taiwan |
IPD may be shared after the results have been published in peer review journals.
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| ID | Term |
|---|---|
| D033461 | Hyperuricemia |
| D024821 | Metabolic Syndrome |
| ID | Term |
|---|---|
| D010335 | Pathologic Processes |
| D013568 | Pathological Conditions, Signs and Symptoms |
| D007333 | Insulin Resistance |
| D006946 | Hyperinsulinism |
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| My Plate - Low Purine | Other | Participants will attend group lessons and individual nutrition counseling to help them adopt a balanced diet in accordance with my plate, and emphasis on choosing low purine options from the protein food groups. |
|
| Amla fruits | Other | Participants will be provided with powdered amla fruits, and will be instructed to take 3g per day. |
|
| Lipid profile | cholesterol | 3 months |
| vitamin B12 | serum vitamin B12 | 3 months |
| holostranscobalamin | serum holotranscobalamin | 3 months |
| homocysteine | serum homocysteine | 3 months |
| vitamin D | serum 25(OH)D | 3 months |
| D044882 | Glucose Metabolism Disorders |
| D008659 | Metabolic Diseases |
| D009750 | Nutritional and Metabolic Diseases |