Vegan vs AHA Diet on Inflammation and Glucometabolic Profile in Patients With CAD

Effects of a Whole-food Plant-based Vegan Diet on Markers of Inflammation and Glucometabolic Profile in Patients With Coronary Artery Disease

In this randomized study the investigators aim to determine the effects of a whole-food plant-based vegan diet on markers of inflammation and glucometabolic profile in patients with cardiovascular disease. The investigators hypothesize that a whole-food plant-based vegan diet will reduce markers of inflammation and improve glucometabolic profile compared with the American Heart Association (AHA)- recommended diet at 2 months follow-up in patients with coronary artery disease (CAD). The investigators are also evaluating endothelial function using the EndoPAT device and stool microbiome.

Inclusion Criteria:

• Subjects on stable medical therapy for at least 7-10 days post-coronary angiography and found to have CAD (defined as >50% lesion in an artery with >2mm caliber) .

Exclusion Criteria:

• Failure of the Treatment Self-Regulation Questionnaire
• Use of steroids or non-steroidal anti-inflammatory medications other than aspirin
• Use of probiotics or over the counter supplements other than standard vitamins
• Have a history of myocardial infarction or active infection within the preceding 3 months
• Have a history of an eating disorder or colon cleansing or are already on a whole-food plant-based vegan diet
• Have a planned PCI during the study period
• Are participating in a competing study
• Have any condition or situation that, in the investigator's opinion, may confound the study results, or may interfere significantly with the patient's ability to adhere with study procedures