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The role of diet in preventing hypertension and cardiovascular diseases in African Americans, who have a much higher risk of developing these diseases, is not well understood. Therefore, this project will investigate whether African Americans following a 100% plant-based diet have more optimal blood pressure, vascular function, and blood lipid profiles, along with lower systemic inflammation relative to African Americans following a typical American diet.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Typical American Diet | African American individuals who self-report adhering to a typical American diet prior to enrolling in the study. |
| |
| Plant-Based Diet | African American individuals who self-report adhering to a plant-based diet prior to enrolling in the study. |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Typical American Diet | Other | Participants self-reported adherence to a typical American diet prior to enrolling in the study. This factor determined cross-sectional group allocation. |
| Measure | Description | Time Frame |
|---|---|---|
| Lipid profile (Total-C, LDL-C, VLDL-C, HDL-C, TG) | Day 1 | |
| C-reactive protein | Day 1 | |
| Post-occlusive brachial artery flow-mediated dilation (% change in brachial artery diameter from resting baseline) | Day 1 | |
| Post-occlusive forearm reactive hyperemia (% change in brachial artery blood velocity from resting baseline) | Day 1 | |
| Pulse wave velocity (carotid-to-femoral) | Day 1 | |
| Augmentation index (AIx@HR75) | Day 1 | |
| Cerebral vascular reactivity (% change in cerebrovascular conductance index from resting baseline) | Day 2 | |
| Local cutaneous thermal hyperemia (% change in cutaneous vascular conductance from resting baseline) | Day 2 | |
| Peripheral blood pressure (systolic, diastolic, mean) | Day 1 | |
| Central blood pressure (systolic, diastolic, mean) | Day 1 |
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Inclusion Criteria:
Exclusion Criteria:
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Community sample from the greater Dallas-Fort Worth Metroplex area.
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| Name | Affiliation | Role |
|---|---|---|
| Robert M Brothers, PhD | The University of Texas at Arlington | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| UT Arlington - Science and Engineering Innovation and Research Building | Arlington | Texas | 76019 | United States |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 35512369 | Derived | Martin ZT, Olvera G, Villegas CA, Campbell JC, Akins JD, Brown KK, Brothers RM. The impact of a plant-based diet on indices of cardiovascular health in African Americans: a cross-sectional study. Appl Physiol Nutr Metab. 2022 Sep 1;47(9):903-914. doi: 10.1139/apnm-2022-0027. Epub 2022 May 5. |
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Data Availability Statement: All raw data were collected and generated at the University of Texas at Arlington. Data supporting the findings and conclusions of this study are available from the corresponding author upon request.
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| ID | Term |
|---|---|
| D002318 | Cardiovascular Diseases |
| D006973 | Hypertension |
| D007249 | Inflammation |
| ID | Term |
|---|---|
| D014652 | Vascular Diseases |
| D010335 | Pathologic Processes |
| D013568 | Pathological Conditions, Signs and Symptoms |
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| ID | Term |
|---|---|
| D000095500 | Diet, Plant-Based |
| ID | Term |
|---|---|
| D004035 | Diet Therapy |
| D044623 | Nutrition Therapy |
| D013812 | Therapeutics |
| D004032 | Diet |
| D009747 |
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stored serum
| Plant-Based Diet | Other | Participants self-reported adherence to a 100% plant-based diet prior to enrolling in the study. This factor determined cross-sectional group allocation. |
|
| Nutritional Physiological Phenomena |
| D000066888 | Diet, Food, and Nutrition |
| D010829 | Physiological Phenomena |