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Systematic inflammation and lipid profiles are two major therapeutic targets for cardiovascular diseases. The effectiveness of vegan diet has been reported (doi: 10.3389/fnut.2022.807810).
Aim:
To compare the effectiveness of a nutritionally balanced vegan diet and a Myplate diet ((Taiwanese version) on systematic inflammation and lipoprotein subclass.
Design: Randomized crossover design
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Vegan diet | Experimental | Participants were provided with and instructed to eat these foods:
Each Participant has three group sessions and three individual nutrition counseling with a dietitian. |
|
| MyPlate (Taiwanese version) | Active Comparator | Each Participant has three group sessions and three individual nutrition counseling with a dietitian. |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Vegan diet | Behavioral | The participants were advised to eat foods in their original type. |
|
| Measure | Description | Time Frame |
|---|---|---|
| Novel inflammatory markers for cardiovascular disease and Lipoprotein particles concentration | GlycA (umol/L), lipoprotein particles concentration(umol/L) | 12 weeks |
| Lipoprotein particles concentration | lipoprotein particles concentration (nmol/L） | 12 weeks |
| lipoprotein particles size | lipoprotein particles size (nm) | 12 weeks |
| Trimethylamine-N-oxide | TMAO (uM). TMAO is a low molecular weight compound that belongs to the class of amine oxides | 12 weeks |
| Traditional cadiometabolic risk factors 1 | TG(mg/dL), LDL-C(mg/dL), HDL-C(mg/dL), Total cholesterol(mg/dL) | 12 weeks |
| Traditional cadiometabolic risk factors 2 | HbA1c(%) | 12 weeks |
| Traditional cadiometabolic risk factors 3 | HOMA-IR index (Homeostasis Model Assessment-Insulin Resistance index) | 12 weeks |
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Inclusion Criteria:
Patients with dyslipidemia (at least one of the following)
Exclusion Criteria (fulfill one of the following condition):
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| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Hualien Tzu Chi Hospital | Hualien City | Taiwan |
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| ID | Term |
|---|---|
| D002318 | Cardiovascular Diseases |
| D024821 | Metabolic Syndrome |
| ID | Term |
|---|---|
| D007333 | Insulin Resistance |
| D006946 | Hyperinsulinism |
| D044882 | Glucose Metabolism Disorders |
| D008659 | Metabolic Diseases |
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| ID | Term |
|---|---|
| D000067269 | Diet, Vegan |
| ID | Term |
|---|---|
| D014676 | Diet, Vegetarian |
| D000095500 | Diet, Plant-Based |
| D004035 | Diet Therapy |
| D044623 | Nutrition Therapy |
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| D009750 |
| Nutritional and Metabolic Diseases |
| D013812 |
| Therapeutics |
| D004032 | Diet |
| D009747 | Nutritional Physiological Phenomena |
| D000066888 | Diet, Food, and Nutrition |
| D010829 | Physiological Phenomena |