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This is a single center patient registry of patients receiving a transjugular intrahepatic portosystemic shunt (TIPS) at Hannover Medical School. By collecting and analyzing clinical data as well as blood samples, the overall aim is to optimize TIPS therapy (e.g. specify selection criteria).
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| TIPS insertion |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| TIPS insertion | Procedure | Patients are included in the registry if they receive a transjugular intrahepatic portosystemic shunt at Hannover Medical School and provide written informed consent. |
| Measure | Description | Time Frame |
|---|---|---|
| Mortality | Patients who die within 1 year | 1 year |
| Occurrence of (Minimal) Hepatic Encephalopathy | Using the Portosystemic encephalopathy (PSE) syndrome test, critical flicker frequency (CFF) and animal naming test (S-ANT) | 1 year |
| Change in Nutritional Status | Nutritional Status will be measured by hand grip strength (dynamometer) in kg | 1 year |
| Change in Quality of Life | Using the questionnaire short-form 36 (SF36) (Score range 0-100, higher scores correspond to better quality of life) | 1 year |
| Measure | Description | Time Frame |
|---|---|---|
| Change in inflammatory markers (e.g. cytokine) | Different cytokines and markers of bacterial translocation (e.g. LPS) are measured | 12 months |
| Change in different metabolites using mass spectroscopy (metabolomics measurements) |
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Inclusion Criteria:
Exclusion Criteria:
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Patients with decompensated liver cirrhosis and an indication for TIPS placement at Hannover Medical School.
| Name | Role | Phone | Extension | |
|---|---|---|---|---|
| Benjamin Maasoumy, PD | Contact | +49 511 532-6529 | Maasoumy.Benjamin@mha-hannover.de |
| Name | Affiliation | Role |
|---|---|---|
| Benjamin Maasoumy, PD | Hannover Medical School | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Hannover Medical School | Recruiting | Hanover | Lower Saxony | 30625 | Germany |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 42261201 | Derived | Dinkelborg K, Niehaus C, Bremer B, Wundes C, Tiede A, Petruch N, Deterding K, Kraft ARM, Hartleben B, Cornberg M, Wedemeyer H, Behrendt P, Maasoumy B. Acute HEV Infection Is a Relevant Cause of Decompensation and ACLF in Patients With Liver Cirrhosis. Liver Int. 2026 Jul;46(7):e70727. doi: 10.1111/liv.70727. | |
| 40782353 | Derived |
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| ID | Term |
|---|---|
| D006975 | Hypertension, Portal |
| D001201 | Ascites |
| D008103 | Liver Cirrhosis |
| ID | Term |
|---|---|
| D008107 | Liver Diseases |
| D004066 | Digestive System Diseases |
| D010335 | Pathologic Processes |
| D013568 | Pathological Conditions, Signs and Symptoms |
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More than 300 metabolites will be measured
| 12 months |
| Analysis of cellular immunity by collection of peripheral blood mononuclear cells (PBMCs) | Fluorescence activated cell sorting (FACS) analysis, genetics and in vitro stimulation assays will be performed | 12 months |
| Analysis of stool samples | Analysis of the intestinal microbiome and metagenome analysis (shotgun sequencing) | 12 months |
| Measurement of portal hypertension | Measurement of the hepatic venous pressure gradient (HVPG) to ensure the efficacy of the TIPS insertion | 6 months |
| Sandmann L, Egge JFM, Tiede A, Ehrenbauer AF, Kabelitz MA, Rieland H, Mauz JB, Meyer BC, Wedemeyer H, Weissenborn K, Maasoumy B. Plasma Ammonia Levels Predict Hepatic Encephalopathy After Transjugular Intrahepatic Portosystemic Shunt Placement. United European Gastroenterol J. 2025 Sep;13(7):1171-1183. doi: 10.1002/ueg2.70095. Epub 2025 Aug 9. |
| 40751304 | Derived | Kabelitz MA, Gairing SJ, Tiede A, Schleicher EM, Ahl LG, Wagner L, Zucker-Reimann F, Rieland H, Mauz JB, Weinmann-Menke J, Meyer BC, Pitton MB, Wedemeyer H, Galle PR, Sandmann L, Maasoumy B, Labenz C. Impact of Frailty on the Prognosis of Patients With Liver Cirrhosis Undergoing Insertion of a TIPS. Aliment Pharmacol Ther. 2026 Jan;63(1):109-118. doi: 10.1111/apt.70315. Epub 2025 Aug 1. |
| 37600959 | Derived | Ehrenbauer AF, Schneider H, Stockhoff L, Tiede A, Lorenz C, Dirks M, Witt J, Gabriel MM, Wedemeyer H, Hinrichs JB, Weissenborn K, Maasoumy B. Predicting overt hepatic encephalopathy after TIPS: Value of three minimal hepatic encephalopathy tests. JHEP Rep. 2023 Jun 28;5(9):100829. doi: 10.1016/j.jhepr.2023.100829. eCollection 2023 Sep. |
| D005355 | Fibrosis |