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Evaluation of non-invasive prognostic parameters in patients receiving transjugular intrahepatic portosystemic shunt (TIPS) for complications of portal hypertension. Patients are cared according to the local standardized follow up program. Clinical and laboratory data from standard patient care are evaluated for potential prognostic value.
NEPTUN consists of liver cirrhosis receiving transjugular intrahepatic portosystemic shunt (TIPS) at the Department of Internal Medicine I, University of Bonn, Germany and receiving a structured routine evaluation and follow up program. The diagnosis of cirrhosis was based on clinical, hemodynamic and biochemical parameters, and ultrasound and/or biopsy criteria.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Retrospective 1 | Retrospective Bare Metal Stent Cohort that received TIPS from 01/01/1996 to 12/31/2003. | ||
| Retrospective 2 | Retrospective Covered Stent Cohort that received TIPS from 01/01/2004 to 12/31/2012. | ||
| Prospective | Prospective cohort that received TIPS from 01/01/2013 onwards |
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| Measure | Description | Time Frame |
|---|---|---|
| Survival | death, liver transplantation | up to 10 years |
| Measure | Description | Time Frame |
|---|---|---|
| Ascites | Evaluation of amount of ascites according to the Child-Score | up to 10 years |
| Hepatic Encephalopathy | Evaluation of the grade according to the West Haven Criteria |
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Inclusion Criteria:
Exclusion Criteria:
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All patients receiving TIPS according to guidelines
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| Name | Affiliation | Role |
|---|---|---|
| Michael Praktiknjo, MD | University of Bonn | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| University Hospital Bonn | Bonn | Germany |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 40202365 | Derived | Meyer C, Kimmann M, Bohm K, Nowak S, Perez AMP, Meier JA, Reinartz Groba SN, Godiker J, Uschner FE, Sanoubara F, Chang J, Trebicka J, Sprinkart AM, Praktiknjo M. Three-Dimensional Transjugular Intrahepatic Portosystemic Shunt Geometry Predicts Shunt Dysfunction. Aliment Pharmacol Ther. 2025 Jun;61(11):1805-1814. doi: 10.1111/apt.70133. Epub 2025 Apr 9. | |
| 35869810 |
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| ID | Term |
|---|---|
| D006975 | Hypertension, Portal |
| ID | Term |
|---|---|
| D008107 | Liver Diseases |
| D004066 | Digestive System Diseases |
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serum, plasma, stool, DNA, PBMC, Buffi coat
| up to 10 years |
| Variceal Bleeding | Assessment of presence of variceal bleeding | up to 10 years |
| Liver Failure | defined as Bilirubin level ≥ 12mg/dl | up to 10 years |
| Acute-on-Chronic-Liver Failure (ACLF) | Presence of ACLF according to the EASL-Chronic liver Failure Consortium (CLIF)-criteria | up to 10 years |
| Organ Failures | Assessment of Organ failures according to the CLIF-SOFA according to CLIF-Sequential Organ Failure Assessment (SOFA) Score | up to 10 years |
| Queck A, Schwierz L, Gu W, Ferstl PG, Jansen C, Uschner FE, Praktiknjo M, Chang J, Brol MJ, Schepis F, Merli M, Strassburg CP, Lehmann J, Meyer C, Trebicka J. Targeted decrease of portal hepatic pressure gradient improves ascites control after TIPS. Hepatology. 2023 Feb 1;77(2):466-475. doi: 10.1002/hep.32676. Epub 2022 Aug 12. |
| 34013182 | Derived | Praktiknjo M, Abu-Omar J, Chang J, Thomas D, Jansen C, Kupczyk P, Schepis F, Garcia-Pagan JC, Merli M, Meyer C, Strassburg CP, Pieper CC, Trebicka J. Controlled underdilation using novel VIATORR(R) controlled expansion stents improves survival after transjugular intrahepatic portosystemic shunt implantation. JHEP Rep. 2021 Mar 3;3(3):100264. doi: 10.1016/j.jhepr.2021.100264. eCollection 2021 Jun. |
| 31448496 | Derived | Torner M, Mangal A, Scharnagl H, Jansen C, Praktiknjo M, Queck A, Gu W, Schierwagen R, Lehmann J, Uschner FE, Graf C, Strassburg CP, Fernandez J, Stojakovic T, Woitas R, Trebicka J. Sex specificity of kidney markers to assess prognosis in cirrhotic patients with TIPS. Liver Int. 2020 Jan;40(1):186-193. doi: 10.1111/liv.14230. Epub 2019 Sep 10. |
| 30739387 | Derived | Lehmann J, Praktiknjo M, Nielsen MJ, Schierwagen R, Meyer C, Thomas D, Violi F, Strassburg CP, Bendtsen F, Moller S, Krag A, Karsdal MA, Leeming DJ, Trebicka J. Collagen type IV remodelling gender-specifically predicts mortality in decompensated cirrhosis. Liver Int. 2019 May;39(5):885-893. doi: 10.1111/liv.14070. Epub 2019 Mar 7. |