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Evaluation of non-invasive prognostic parameters in patients receiving transjugular intrahepatic portosystemic shunt (TIPS) for complications of portal hypertension. Patients are cared according to the local standardized follow up program. Clinical and laboratory data from standard patient care are evaluated for potential prognostic value.
NEPTUN consists of liver cirrhosis receiving transjugular intrahepatic portosystemic shunt (TIPS) at the Department of Internal Medicine I, University of Bonn, Germany and receiving a structured routine evaluation and follow up program. The diagnosis of cirrhosis was based on clinical, hemodynamic and biochemical parameters, and ultrasound and/or biopsy criteria.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Prospective | Prospective cohort that received TIPS from 05/12/2020 onwards |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| TIPS procedure | Device | Implantation of TIPS for portal hypertension |
|
| Measure | Description | Time Frame |
|---|---|---|
| Survival | death, liver transplantation | up to 10 years |
| Measure | Description | Time Frame |
|---|---|---|
| Ascites | Evaluation of amount of ascites according to the Child-Score (0=none;1=moderate/treatable; 2=severe/refractory) | up to 10 years |
| Hepatic Encephalopathy (HE) | Evaluation of the grade according to the West Haven Criteria (Grade 0 (no HE) - Grade 4 (hepatic coma)) |
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Inclusion Criteria:
Exclusion Criteria:
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All patients receiving TIPS according to guidelines
| Name | Role | Phone | Extension | |
|---|---|---|---|---|
| Michael Praktiknjo, MD | Contact | +49(0)228-287 15770 | michael.praktiknjo@ukbonn.de | |
| Johannes Chang, MD | Contact | +49(0)228-287 15770 | johannes.chang@ukbonn.de |
| Name | Affiliation | Role |
|---|---|---|
| Michael Praktiknjo, MD | University of Bonn | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| University Hospital Bonn | Recruiting | Bonn | Germany |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 41204773 | Derived | Heger LA, Chang J, Rohrer C, Reincke M, Eyth A, Sturm L, Schultheiss M, Maier A, Meyer C, Jansen C, Graf K, Ozturk C, Schneider F, Trebicka J, Westermann D, Thimme R, Grundmann S, Praktiknjo M, Bettinger D. Right Ventricular Contractility Predicts Clearance of Ascites After Transjugular Intrahepatic Portosystemic Shunt. Liver Int. 2025 Dec;45(12):e70422. doi: 10.1111/liv.70422. |
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| ID | Term |
|---|---|
| D006975 | Hypertension, Portal |
| ID | Term |
|---|---|
| D008107 | Liver Diseases |
| D004066 | Digestive System Diseases |
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serum, plasma, stool, ascites, DNA, PBMC, Buffi coat
| up to 10 years |
| Variceal Bleeding | Assessment of presence of variceal bleeding | up to 10 years |
| Liver Failure | defined as Bilirubin level ≥ 12mg/dl | up to 10 years |
| Acute-on-Chronic Liver Failure (ACLF) | Presence of ACLF according to the EASL-Chronic liver Failure Consortium (CLIF)-criteria | up to 10 years |
| Organ Failures | Assessment of Organ failures according to CLIF-Sequential Organ Failure Assessment (SOFA) Score (Score 6 (best) to 18 (worst)) | up to 10 years |
| Kidney Failure | Assessment of AKI according to KDIGO definition | up to 10 years |
| Sarcopenia | Assessment of sarcopenia according to EASL-guideline definition | up to 10 years |
| post-surgical survival | Assessment of post-surgical survival | up to 10 years |