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Periodontitis and inflammatory bowel disease have been associated by meta-epidemiologic evidence, although their mechanistic connection needs to be further explored. Oral-gut axis is implicated in the pathogenesis of several chronic inflammatory conditions, but to date no studies have evaluated the impact of periodontal treatment on gut ecology. Thus, the present randomised clinical trial is aimed at investigating the effect of intensive or conventional periodontal therapy on the gut microbiome and parameters of systemic inflammation of patients diagnosed with inflammatory bowel disease.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Intensive periodontal treatment | Experimental | Adjunctive full-mouth intensive removal of subgingival dental plaque biofilms with the use of scaling and root planing after the administration of local anesthesia. |
|
| Community-based periodontal care | Active Comparator | Standard cycle of supragingival mechanical scaling and polishing. |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Full mouth scaling and root planing (FMSRP) | Procedure | Subgingival instrumentation with ultrasonic devices and curettes of all periodontal pockets completed within 48 hours |
|
| Measure | Description | Time Frame |
|---|---|---|
| Changes in microbiome alpha diversity measured from stool samples at 3 months | Taxonomic and functional variation of gut bacteria after treatment | Baseline and 90 days |
| Measure | Description | Time Frame |
|---|---|---|
| Changes in microbiome alpha diversity measured from saliva samples at 3 months | Taxonomic and functional variation of salivary bacteria after treatment | Baseline and 90 days |
| Change of the inflammatory markers levels in plasma |
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Inclusion Criteria:
Exclusion Criteria:
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| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| CIR Dental School | Recruiting | Turin | 10126 | Italy |
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| ID | Term |
|---|---|
| D010510 | Periodontal Diseases |
| D064806 | Dysbiosis |
| D007249 | Inflammation |
| ID | Term |
|---|---|
| D009059 | Mouth Diseases |
| D009057 | Stomatognathic Diseases |
| D010335 | Pathologic Processes |
| D013568 | Pathological Conditions, Signs and Symptoms |
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| ID | Term |
|---|---|
| D016745 | Root Planing |
| ID | Term |
|---|---|
| D012534 | Dental Scaling |
| D003777 | Dental Prophylaxis |
| D010517 | Periodontics |
| D003813 | Dentistry |
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Concentration of cytokines and biomarkers in plasma samples
| Baseline and 90 days |
| Changes in mean clinical attachment level (CAL) at 3 months | Variation in CAL after therapy assessed using a millimetre marked manual periodontal probe at 6 sites per tooth element | Baseline and 90 days |
| Changes in periodontal pocket depth (PPD) at 3 months | Variation in PPD after therapy assessed using a millimetre marked manual periodontal probe at 6 sites per tooth element | Baseline and 90 days |
| Changes in full mouth bleeding score (FMBS) at 3 months | Variation in the percentage of bleeding sites after therapy assessed by gentle probing at 6 sites per tooth element | Baseline and 90 days |
| D013357 |
| Subgingival Curettage |
| D011313 | Preventive Dentistry |