Impact of Non-surgical Periodontal Therapy on Oral and Gut Microbiome

Impact of Non-surgical Periodontal Therapy With or Without Antibiotics on Oral and Gut Microbiome in Patients With Stage III/IV and Grade C Periodontitis

Periodontitis is an inflammatory disease characterized by a dysbiotic microbiome which can lead to bone destruction and tooth loss. Several studies had been reported the association to periodontal disease with systemic conditions and this relation suggests and axis that links oral and gut microbiome. In order to clarify the impact of periodontal condition on gut microbiome, we aim to evaluate the clinical, immunological parameters and the microbiological condition by sequencing of subgingival biofilm and stool samples both before and after non-surgical periodontal treatment with and without antibiotics as adjunct.

Inclusion Criteria:

• Diagnosis of Stage III/IV and grade C Periodontitis
• Presence of at least 20 teeth
• Good general health

Exclusion Criteria:

• Pregnant or lactating
• Were suffering from any other systemic diseases (e.g., cardiovascular, diabetes)
• Received antimicrobials in the previous 6 months
• Received a course of periodontal treatment within the last 6 months
• Were taking long-term anti-inflammatory drugs
• Smoking habits