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| ID | Type | Description | Link |
|---|---|---|---|
| 2020-A00305-34 / 1 | Registry Identifier | IDRCB |
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The general purpose of this research project is to analyze the specific role of motor imagery on motor learning, assessed through corticospinal excitability measurements and behavioral data collection. This project is based on four sequences. For Sequence 1, the main objective is to examine the effect of mental training on movement speed and accuracy in a manual motor sequence task, as well as the influence of sensory feedback in immediate post-test (i.e., execution of a similar, but not identical, manual motor sequence, other manual tasks) on performance in delayed post-test. The secondary objective will be to examine corticospinal changes (i.e., amplitude of motor evoked potentials) induced by mental training, by measuring the amplitude of motor evoked potentials before and after mental training. For Sequence 2, the main objective is to examine the impact of a motor disturbance induced by a robotic arm at different intervals during the motor imagery process. The secondary objective will be to examine the corticospinal changes (i.e. amplitude of evoked motor potentials) induced by mental training as a function of the applied perturbations, before and after perturbation. For Sequence 3, the main objective will be to examine the influence of neuroplasticity on the quality of mental training. More specifically, the investigators will study the links between brain plasticity and motor learning through mental training. The secondary objective will be to examine the corticospinal changes (i.e. amplitude of evoked motor potentials) induced by mental training at different levels of the neuromuscular system (cortical, cervicomedullar, peripheral) after a training period. For Sequence 4, the main objective will be to examine the effect of short-term arm-immobilization of on the retention of motor learning induced by mental training. The secondary objective will be to examine the corticospinal changes (i.e., amplitude of motor evoked potentials) induced by of short-term arm-immobilization, or by transcranial direct current stimulation (tDCS), on motor learning. The results of this fundamental research project will allow a better understanding of neurophysiological and behavioral mechanisms that underlie motor learning through motor imagery. The results will allow to efficiently consider inter-individual specificities and will thus open up to clinical research perspectives, towards the establishment of adapted motor rehabilitation protocols.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Sequence 1 - Training with same task - Long follow-up | Experimental | Motor task (Pretest and Posttests on the same task) Transcranial magnetic stimulation Mental training |
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| Sequence 1 - Training with same task - Short follow-up | Experimental | Motor task (Pretest and Posttests on the same task) Transcranial magnetic stimulation Mental training |
|
| Sequence 1 - Training with different tasks - Long follow-up | Experimental | Motor task (different task in immediate post test) Transcranial magnetic stimulation Mental training |
|
| Sequence 1 - Training with different tasks - Short follow-up | Experimental | Motor task (different task in immediate post test) Transcranial magnetic stimulation Mental training |
|
| Sequence 1 - Training with muscle contractions - Long follow-up | Experimental |
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Transcranial magnetic stimulation | Device | Magnetic stimulation of the cortex |
|
| Measure | Description | Time Frame |
|---|---|---|
| Evolution of movement speed - Sequence 1 | The duration of performed movement sequences | Each day in Sequence 1 (Sequence 1 is 11 days) |
| Evolution of movement accuracy - Sequence 1 | The accuracy of performed movement sequences (i.e., the correspondence between the performed finger motor sequences and the requested finger motor sequence). | Each day in Sequence 1 (Sequence 1 is 11 days) |
| Evolution of trajectory error - Sequence 2 | The area under the curve of hand's trajectory according to the straight line joining the starting target and the final target. | Each day in Sequence 2 (Sequence 1 is 10 days) |
| Evolution of maximal deviation - Sequence 2 | The maximal perpendicular distance between the position of the hand and the straight line joining the starting target and the final target | Each day in Sequence 2 (Sequence 1 is 10 days) |
| Evolution of final error - Sequence 2 | The distance between the final position of the hand and the position of the final target. | Each day in Sequence 2 (Sequence 1 is 10 days) |
| Evolution of movement speed - Sequence 3 | The duration of performed movement sequences | Each day from day 2 to day 11 of Sequence 3 (Sequence 3 is 11 days) |
| Evolution of movement accuracy - Sequence 3 |
| Measure | Description | Time Frame |
|---|---|---|
| Evolution of motor evoked potentials amplitude - Sequence 1 | Peak-to-peak amplitude of motor evoked potentials | Day 1, 5, 6, 10 and 11 in Sequence 1 (Sequence 1 is 11 days). |
| Evolution of motor evoked potentials amplitude - Sequence 2 |
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Inclusion Criteria:
Exclusion Criteria:
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| Name | Role | Phone | Extension | |
|---|---|---|---|---|
| Florent Lebon, PhD | Contact | +33 3 80 39 67 49 | florent.lebon@u-bourgogne.fr |
| Name | Affiliation | Role |
|---|---|---|
| Florent Lebon, PhD | Institut National de la Santé Et de la Recherche Médicale, France | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| INSERM - U1093 Cognition, Action, and Sensorimotor Plasticity | Recruiting | Dijon | France |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 18401345 | Background | Abraham WC. Metaplasticity: tuning synapses and networks for plasticity. Nat Rev Neurosci. 2008 May;9(5):387. doi: 10.1038/nrn2356. | |
| 23737857 | Background | Anwar MN, Khan SH. Trial-by-trial adaptation of movements during mental practice under force field. Comput Math Methods Med. 2013;2013:109497. doi: 10.1155/2013/109497. Epub 2013 May 7. |
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| Type | Includes Protocol | Includes SAP | Includes ICF | Document Label | Document Date | Document Uploaded Date | Document File Name |
|---|---|---|---|---|---|---|---|
| Prot_SAP | Yes | Yes | No | Study Protocol and Statistical Analysis Plan | Nov 25, 2020 |
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Motor task (isometric muscle contractions in immediate post test) Transcranial magnetic stimulation Mental training
|
| Sequence 1 - Training with muscle contractions - Short follow-up | Experimental | Motor task (isometric muscle contractions in immediate post test) Transcranial magnetic stimulation Mental training |
|
| Sequence 1 - Control | Active Comparator | Motor task (Pretest and Posttests on the same task) Transcranial magnetic stimulation No mental training |
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| Sequence 2 - Physical training with perturbation during preparation - Long follow-up | Active Comparator | Motor task (Pretest and Posttests) Transcranial magnetic stimulation External pertubation (robotic arm) Physical training |
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| Sequence 2 - Physical training with perturbation during preparation - Short follow-up | Active Comparator | Motor task (Pretest and Posttests) Transcranial magnetic stimulation External pertubation (robotic arm) Physical training |
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| Sequence 2 - Physical training with perturbation after preparation - Long follow-up | Active Comparator | Motor task (Pretest and Posttests) Transcranial magnetic stimulation External pertubation (robotic arm) Physical training |
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| Sequence 2 - Physical training with perturbation after preparation - Short follow-up | Active Comparator | Motor task (Pretest and Posttests) Transcranial magnetic stimulation External pertubation (robotic arm) Physical training |
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| Sequence 2 - Mental training with perturbation during preparation - Long follow-up | Experimental | Motor task (Pretest and Posttests) Transcranial magnetic stimulation External pertubation (robotic arm) Mental training |
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| Sequence 2 - Mental training with perturbation during preparation - Short follow-up | Experimental | Motor task (Pretest and Posttests) Transcranial magnetic stimulation External pertubation (robotic arm) Mental training |
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| Sequence 2 - Mental training with perturbation after preparation - Long follow-up | Experimental | Motor task (Pretest and Posttests) Transcranial magnetic stimulation External pertubation (robotic arm) Mental training |
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| Sequence 2 - Mental training with perturbation after preparation - Short follow-up | Experimental | Motor task (Pretest and Posttests) Transcranial magnetic stimulation External pertubation (robotic arm) Mental training |
|
| Sequence 3 - Training (same task) - Long follow-up | Experimental | Paired Associative Stimulation Mental training (same as the motor task) Motor task Transcranial magnetic stimulation Peripheral nerve stimulation Cervicomedullar stimulation |
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| Sequence 3 - Training (same task) - Short follow-up | Experimental | Paired Associative Stimulation Mental training (same as the motor task) Motor task Transcranial magnetic stimulation Peripheral nerve stimulation Cervicomedullar stimulation |
|
| Sequence 3 - Training (different task) - Long follow-up | Experimental | Paired Associative Stimulation Mental training (different of the motor task) Motor task Transcranial magnetic stimulation Peripheral nerve stimulation Cervicomedullar stimulation |
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| Sequence 3 - Training (different task) - Short follow-up | Experimental | Paired Associative Stimulation Mental training (different of the motor task) Motor task Transcranial magnetic stimulation Peripheral nerve stimulation Cervicomedullar stimulation |
|
| Sequence 3 - Control 1 | Active Comparator | Mental Training Motor task (same as the motor task) Transcranial magnetic stimulation Peripheral nerve stimulation Cervicomedullar stimulation |
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| Sequence 3 - Control 2 | Active Comparator | Paired Associative Stimulation Motor task Transcranial magnetic stimulation Peripheral nerve stimulation Cervicomedullar stimulation |
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| Sequence 4 - Immobilization - Short follow-up | Experimental | Transcranial magnetic stimulation Arm immobilization Motor task Mental training |
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| Sequence 4 - Immobilization - Long follow-up | Experimental | Transcranial magnetic stimulation Arm immobilization Motor task Mental training |
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| Sequence 4 - Cathodal - Short follow-up | Experimental | Transcranial magnetic stimulation Cathodal transcranial direct current stimulation Motor task Mental training |
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| Sequence 4 - Cathodal - Long follow-up | Experimental | Transcranial magnetic stimulation Cathodal transcranial direct current stimulation Motor task Mental training |
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| Sequence 4 - Anodal - Short follow-up | Experimental | Transcranial magnetic stimulation Anodal transcranial direct current stimulation Motor task Mental training |
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| Sequence 4 - Anodal - Long follow-up | Experimental | Transcranial magnetic stimulation Anodal transcranial direct current stimulation Motor task Mental training |
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| Sequence 4 - Control | Sham Comparator | Transcranial magnetic stimulation Motor task Mental training |
|
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| Peripheral Nerve Stimulation | Device | Electric stimulation of the nerves |
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| Transcranial direct current stimulation | Device | Electric stimulation of the cortex |
|
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| Paired Associative Stimulation | Device | Combined magnetic and electric stimulation of cortex and nerve, respectively |
|
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| Wrist | Device | Short-term immobilization of the arm |
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| Robotic arm | Device | External perturbation of force field induced by robotic arm |
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| Cervicomedullar stimulation | Device | Electric stimulation of the muscle |
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| Physical training | Other | Training to perform the task by actually doing the task |
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| Mental training | Other | Training to perform the task by imaging doing the task |
|
The accuracy of performed movement sequences (i.e., the correspondence between the performed finger motor sequences and the requested finger motor sequence).
| Each day from day 2 to day 11 of Sequence 3 (Sequence 3 is 11 days) |
| Evolution of movement speed - Sequence 4 | The duration of performed movement sequences | Each day in Sequence 4 (Sequence 4 is 6 days) |
| Evolution of movement accuracy - Sequence 4 | The accuracy of performed movement sequences (i.e., the correspondence between the performed finger motor sequences and the requested finger motor sequence). | Each day in Sequence 4 (Sequence 4 is 6 days) |
Peak-to-peak amplitude of motor evoked potentials
| Each day in Sequence 2 (Sequence 2 is 10 days) |
| Evolution of motor evoked potentials amplitude - Sequence 3 | Peak-to-peak amplitude of motor evoked potentials | Day 1, 5, 6, 10 and 11 in Sequence 3 (Sequence 1 is 11 days) |
| Evolution of motor evoked potentials amplitude - Sequence 4 | Peak-to-peak amplitude of motor evoked potentials | Days 1, 5, and 6 in Sequence 4 (Sequence 4 is 6 days) |
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| 23319043 | Background | Burianova H, Marstaller L, Sowman P, Tesan G, Rich AN, Williams M, Savage G, Johnson BW. Multimodal functional imaging of motor imagery using a novel paradigm. Neuroimage. 2013 May 1;71:50-8. doi: 10.1016/j.neuroimage.2013.01.001. Epub 2013 Jan 12. |
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| 11811570 | Background | Cumming J, Hall C. Deliberate imagery practice: the development of imagery skills in competitive athletes. J Sports Sci. 2002 Feb;20(2):137-45. doi: 10.1080/026404102317200846. |
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| 15831397 | Background | Doyon J, Benali H. Reorganization and plasticity in the adult brain during learning of motor skills. Curr Opin Neurobiol. 2005 Apr;15(2):161-7. doi: 10.1016/j.conb.2005.03.004. |
| 20538766 | Background | Gentili R, Han CE, Schweighofer N, Papaxanthis C. Motor learning without doing: trial-by-trial improvement in motor performance during mental training. J Neurophysiol. 2010 Aug;104(2):774-83. doi: 10.1152/jn.00257.2010. Epub 2010 Jun 10. |
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| 15736871 | Background | Grush R. The emulation theory of representation: motor control, imagery, and perception. Behav Brain Sci. 2004 Jun;27(3):377-96; discussion 396-442. doi: 10.1017/s0140525x04000093. |
| 23425312 | Background | Guillot A, Moschberger K, Collet C. Coupling movement with imagery as a new perspective for motor imagery practice. Behav Brain Funct. 2013 Feb 20;9:8. doi: 10.1186/1744-9081-9-8. |
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| 21423711 | Background | Izawa J, Shadmehr R. Learning from sensory and reward prediction errors during motor adaptation. PLoS Comput Biol. 2011 Mar;7(3):e1002012. doi: 10.1371/journal.pcbi.1002012. Epub 2011 Mar 10. |
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| 21682867 | Background | Schuster C, Hilfiker R, Amft O, Scheidhauer A, Andrews B, Butler J, Kischka U, Ettlin T. Best practice for motor imagery: a systematic literature review on motor imagery training elements in five different disciplines. BMC Med. 2011 Jun 17;9:75. doi: 10.1186/1741-7015-9-75. |
| Nov 25, 2020 |
| Prot_SAP_000.pdf |
| ID | Term |
|---|---|
| D050781 | Transcranial Magnetic Stimulation |
| D065908 | Transcranial Direct Current Stimulation |
| D064797 | Physical Conditioning, Human |
| ID | Term |
|---|---|
| D055909 | Magnetic Field Therapy |
| D013812 | Therapeutics |
| D004599 | Electric Stimulation Therapy |
| D003295 | Convulsive Therapy |
| D013000 | Psychiatric Somatic Therapies |
| D004191 | Behavioral Disciplines and Activities |
| D004597 | Electroshock |
| D011580 | Psychological Techniques |
| D015444 | Exercise |
| D009043 | Motor Activity |
| D009068 | Movement |
| D009142 | Musculoskeletal Physiological Phenomena |
| D055687 | Musculoskeletal and Neural Physiological Phenomena |
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