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Study withdrawn before enrollment due to resource constraints. No participants were enrolled.
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This study aims to evaluate three different transcranial magnetic stimulation protocols and their impact on motor system neurophysiology and skill learning.
Transcranial magnetic stimulation (TMS) is a non-invasive brain stimulation method that induces long-term changes in connections between neuronal networks. This and the ability to activate the whole motor system allows the use of TMS to facilitate motor recovery. The motor system has different excitatory states associated with ongoing mu oscillation. Here, the investigators will monitor brain mu oscillations in real-time non-invasively using electroencephalography and modulate the function of the motor system. The investigators will test the impact of three different TMS protocols on motor system neurophysiology and skill learning. These data will provide novel understanding needed to improve TMS approaches for individuals requiring motor rehabilitation.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Single-pulse TMS over the primary motor cortex | Experimental | We will administer single-pulse TMS to the primary motor cortex while measuring motor responses and just before a skill-learning task. |
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| Paired-pulse TMS over the primary motor cortex | Experimental | We will administer paired-pulse TMS to the primary motor cortex while measuring motor responses and just before a skill-learning task. |
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| Sham TMS over the primary motor cortex | Sham Comparator | We will administer sham TMS to the primary motor cortex while measuring motor responses and before a skill-learning task. |
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| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Transcranial Magnetic Stimulation (TMS) | Device | Transcranial magnetic stimulation (TMS) is a non-invasive brain stimulation method that can induce long-term changes in connections between neuronal networks. |
| Measure | Description | Time Frame |
|---|---|---|
| Effect of TMS on motor evoked potentials | Amplitude of the motor evoked potentials in millivolts. | Up to 1 second after TMS |
| Skill learning accuracy | Skill learning accuracy as the total number of correct responses. | Up to 12 minutes |
| Skill learning speed | Skill learning speed in seconds. | Up to 12 minutes |
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Inclusion Criteria:
Exclusion Criteria:
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| Name | Affiliation | Role |
|---|---|---|
| Elisa Kallioniemi, Ph.D. | New Jersey Institute of Technology | Principal Investigator |
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Preprocessed and anonymized data will be provided upon request to the faculty / research staff of recognized research, medical, and educational institutions for educational and scientific purposes.
Data will be shared only upon request after the study has ended (within 6 months).
To receive access, the study investigators must be contacted via an institutional e-mail.
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| ID | Term |
|---|---|
| D050781 | Transcranial Magnetic Stimulation |
| ID | Term |
|---|---|
| D055909 | Magnetic Field Therapy |
| D013812 | Therapeutics |
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