To Evaluate the Performance and Safety of YVOIRE Volume Plus for Improvement of Mid-face Volume

A Randomized, Multicenter, Evaluator-Blinded, Active-Controlled, Parallel-Group Design Investigation to Evaluate Performance and Safety of YVOIRE Volume Plus Versus Restylane Lyft with Lidocaine for Temporary Improvement of Mid-face Volume

A Study to Evaluate the Performance and Safety of YVOIRE volume plus for Temporary Improvement of Mid-face Volume

This is a Randomized, Multicenter, Evaluator-Blinded, Active-Controlled, Parallel-Group Design Investigation to Evaluate the Performance and Safety of YVOIRE volume plus versus Restylane Lyft with Lidocaine for Temporary Improvement of Mid-face Volume.

Inclusion Criteria:

• Male and female aged between 21 to 75 years (inclusive)
• 2 or 3 on the 5-point MFVLRS (Mid Face Volume Loss Rating Scale)
• Desire cheek augmentation to correct volume deficit in the midface.
• Agree to use contraception
• Sign Informed Consent Form

Exclusion Criteria:

• have undergone facial plastic surgery, tissue grafting, or tissue augmentation with silicone, fat, or other permanent, or semi-permanent dermal fillers in the midface area
• have undergone temporary facial dermal filler injections with HA-based fillers within 12 months, porcine-based collagen fillers within 24 months prior to screening
• have mid-face volume deficit due to congenital defect, trauma, abnormalities in adipose tissue related to immune-mediated diseases
• have history of anaphylaxis, multiple severe allergies, or allergy to lidocaine, HA products, or Streptococcal protein
• have history of bleeding disorder
• have a tendency to develop hypertrophic scarring or keloid