A Randomized, Multicenter, Evaluator-Blinded, Active-Controlled, Parallel-Group Investigation to Evaluate the Performance and Safety of YVOIRE® Classic Plus Versus Comparator for Temporary Correction of Nasolabial Folds

A Randomized, Multicenter, Evaluator-Blinded, Active-Controlled, Parallel-Group Investigation to Evaluate the Performance and Safety of YVOIRE® Classic Plus Versus Comparator for Temporary Correction of Nasolabial Folds

A Study to Evaluate the Performance and Safety of YVOIRE Classic plus on NLF.

This is a Randomized, Multicenter, Evaluator-Blinded, Active-Controlled, Parallel-Group Study to Evaluate the Performance and Safety of YVOIRE Classic plus Versus Comparator for Temporary Correction of Nasolabial Folds.

Inclusion Criteria:

• Male or female 21 years or above age.
• 2 or 3 of the 5-point (0-4) NLFRS (Nasolabial Fold Rating Scale).
• Agree to use proper contraception as guided in the protocol.
• Signed for Informed Consent.

Exclusion Criteria:

• have received permanent facial implants anywhere in the face or neck or planning during the investigation.
• have undergone facial plastic surgery of the lower face and nasolabial region within 12 weeks
• have undergone semi-permanent filler in lower face
• have undergone temporary dermal filler treatment in the lower two-thirds of face within 12 months
• Have undergone facial tissue augmentation or facial treatment with fat or botulinum injections in the lower two-thirds of face
• Have undergone mesotherapy or cosmetic procedures in face or neck within 6 months
• have used any over-the-counter anti-wrinkle products or prescription anti-wrinkle medicines for the nasolabial folds within 28 days