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45 sites in 15 patients with periodontal pockets ≥ 5mm were selected. These selected sites were divided into 3 groups as Group A, B and C.
Group A (Control): 15 sites received only SRP, Group B: 15 sites received SRP with subgingival placement of amnion membrane, Group C: 15 sites received SRP with subgingival placement of Amnion membrane hydrated with Taurine.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Group A | Sham Comparator | 15 sites received only scaling and root planing |
|
| Group B | Active Comparator | 15 sites received scaling and root planing with subgingival placement of amnion membrane |
|
| Group C | Active Comparator | 15 sites received scaling and root planing with subgingival placement of amnion membrane hydrated with Taurine |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Scaling and root planing | Procedure | 15 sites with periodontal pockets ≥ 5mm received only SRP |
|
| Measure | Description | Time Frame |
|---|---|---|
| TNF-α level | TNF-α level in Gingival crevicular fluid | changes from baseline to 45 days |
| Probing pocket depth (PPD) | Probing pocket depth at selected site | changes from baseline to 45 days |
| Relative attachment level (RAL) | Relative attachment level from stent to base of the pocket | changes from baseline to 45 days |
| Measure | Description | Time Frame |
|---|---|---|
| Plaque index (PI) | Plaque index (PI) - Silness and Loe 1964 site specific | changes from baseline to 45 days |
| Gingival index (GI) | Gingival index (GI) - Loe and Silness 1963 site specific |
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Inclusion Criteria:
•Systemically healthy patients with sites showing probing depth (PD) ≥ 5mm, clinical attachment level (CAL) ≥ 4 mm, and vertical bone loss ≥ 3 mm on intraoral periapical radiographs with no history of periodontal therapy or use of antibiotics in the preceding 6 months
Exclusion Criteria:
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| Name | Affiliation | Role |
|---|---|---|
| surinder sachdeva, M.D.S. | PROFESSOR | Study Director |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Department of Periodontology, M.M. College of Dental Sciences and Research. | Ambāla | Haryana | 133207 | India |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 18241224 | Background | Giris M, Depboylu B, Dogru-Abbasoglu S, Erbil Y, Olgac V, Alis H, Aykac-Toker G, Uysal M. Effect of taurine on oxidative stress and apoptosis-related protein expression in trinitrobenzene sulphonic acid-induced colitis. Clin Exp Immunol. 2008 Apr;152(1):102-10. doi: 10.1111/j.1365-2249.2008.03599.x. Epub 2008 Jan 28. | |
| 21574832 |
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| ID | Term |
|---|---|
| D010518 | Periodontitis |
| ID | Term |
|---|---|
| D010510 | Periodontal Diseases |
| D009059 | Mouth Diseases |
| D009057 | Stomatognathic Diseases |
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| ID | Term |
|---|---|
| D014080 | Tooth Exfoliation |
| D016745 | Root Planing |
| D013654 | Taurine |
| ID | Term |
|---|---|
| D009063 | Dental Physiological Phenomena |
| D055688 | Digestive System and Oral Physiological Phenomena |
| D012534 | Dental Scaling |
| D003777 | Dental Prophylaxis |
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Group A (Control): 15 sites received only SRP, Group B: 15 sites received SRP with subgingival placement of amnion membrane, Group C: 15 sites received SRP with subgingival placement of Amnion membrane hydrated with Taurine.
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patients and statistician are masked about treatment modality
| Amnion membrane | Biological | 15 sites with periodontal pockets ≥ 5mm received SRP along with placement of amnion membrane. |
|
|
| Taurine | Drug | 15 sites with periodontal pockets ≥ 5mm received SRP along with placement of amnion membrane hydrated with taurine. |
|
|
| changes from baseline to 45 days |
| Bleeding on probing (BOP) | Bleeding on probing (BOP): Muhlemann HR & Son 1971 sit specific | changes from baseline to 45 days |
| Gultekin SE, Senguven B, Sofuoglu A, Taner L, Koch M. Effect of the topical use of the antioxidant taurine on the two basement membrane proteins of regenerating oral gingival epithelium. J Periodontol. 2012 Jan;83(1):127-34. doi: 10.1902/jop.2011.100568. Epub 2011 May 16. |
| D010517 | Periodontics |
| D003813 | Dentistry |
| D013357 | Subgingival Curettage |
| D011313 | Preventive Dentistry |
| D017738 | Alkanesulfonic Acids |
| D000473 | Alkanes |
| D006839 | Hydrocarbons, Acyclic |
| D006838 | Hydrocarbons |
| D009930 | Organic Chemicals |
| D013451 | Sulfonic Acids |
| D013456 | Sulfur Acids |
| D013457 | Sulfur Compounds |