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Omega 3 fatty acids is one such dietary supplement, known to modulate the host response in chronic conditions like cardiovascular diseases, rheumatoid arthritis, ischemic cerebrovascular diseases, osteoporosis by producing Resolvins and protectins without showing any inadvertent effects.Addition of systemic Omega 3 Fatty Acids with SRP may enhance the therapeutic result of Chronic Periodontitis owing to host modulation & anti-inflammatory properties. If proven, this can be used as a routine treatment modality.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Test Group | Active Comparator | Patients with Chronic Periodontitis in Test Group were prescribed Omega 3 fatty acid tablets 300mg once daily for 12 weeks |
|
| Control Group | Placebo Comparator | Patients with Chronic Periodontitis in Control Group were prescribed Placebo tablets once daily for 12 weeks |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Omega 3 fatty acid | Drug | Patients with Chronic Periodontitis in Test Group were prescribed Omega 3 fatty acid tablets 300mg once daily for 12 weeks and SRP at baseline |
|
| Measure | Description | Time Frame |
|---|---|---|
| Change from baseline in serum CRP level at 6 weeks and 12 weeks | changes from baseline in biochemical parameter, serum CRP levels were assessed at 6 weeks and 12 weeks after starting therapy with omega 3 fatty acids. Serum CRP level was measured in milligram/liter (mg/l) | baseline, 6 weeks, 12 weeks |
| Changes from baseline in pocket depth (PD) at 6 weeks and 12 weeks | changes from baseline in clinical parameter, PD were assessed at 6 weeks and 12 weeks after starting therapy with omega 3 fatty acids. PD was measured in millimeter. | baseline, 6 weeks and 12 weeks |
| Changes from baseline in Clinical Attachment Level (CAL) at 6 weeks and 12 weeks. | changes from baseline in clinical parameter, CAL were assessed at 6 weeks and 12 weeks after starting therapy with omega 3 fatty acids. CAL was measured in millimeter. | baseline, 6 weeks and 12 weeks |
| Measure | Description | Time Frame |
|---|---|---|
| Changes from baseline in Gingival Index (GI) at 6 weeks and 12 weeks | changes from baseline in standard clinical parameter, GI were assessed at 6 weeks and 12 weeks after starting therapy with omega 3 fatty acids. GI has a scoring criteria specified by Silness & Loe, 1963. | baseline, 6 weeks and 12 weeks |
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Inclusion Criteria:
Exclusion Criteria:
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| Name | Affiliation | Role |
|---|---|---|
| Girish D Deore, BDS | Post Graduate Student | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Tatyasaheb Kore Dental College and Research Centre, New Pargaon | Kolhāpur | Maharashtra | 416137 | India |
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| ID | Term |
|---|---|
| D055113 | Chronic Periodontitis |
| ID | Term |
|---|---|
| D010518 | Periodontitis |
| D010510 | Periodontal Diseases |
| D009059 | Mouth Diseases |
| D009057 | Stomatognathic Diseases |
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| ID | Term |
|---|---|
| D015525 | Fatty Acids, Omega-3 |
| ID | Term |
|---|---|
| D004042 | Dietary Fats, Unsaturated |
| D004041 | Dietary Fats |
| D005223 | Fats |
| D008055 | Lipids |
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|
| Placebo | Drug | Patients with Chronic Periodontitis in Control Group were prescribed Placebo tablets once daily for 12 weeks and SRP |
|
| Changes from baseline in Plaque Index (PI) at 6 weeks and 12 weeks |
changes from baseline in standard clinical parameter, PI were assessed at 6 weeks and 12 weeks after starting therapy with omega 3 fatty acids. PI has a scoring criteria specified by Loe & Silness, 1964. |
| baseline, 6 weeks and 12 weeks |
| Changes from baseline in Oral Hygiene Index Simplified (OHIS) at 6 weeks and 12 weeks. | changes from baseline in standard clinical parameter, OHIS were assessed at 6 weeks and 12 weeks after starting therapy with omega 3 fatty acids. OHIS has a scoring criteria specified by Greene and Vermilion, 1964. | baseline, 6 weeks and 12 weeks |
| Changes from baseline in Sulcus Bleeding Index (SBI) at 6 weeks and 12 weeks | changes from baseline in standard clinical parameter, SBI were assessed at 6 weeks and 12 weeks after starting therapy with omega 3 fatty acids. SBI has a scoring criteria specified by Muhleman (1971). | baseline, 6 weeks and 12 weeks |
| D002908 |
| Chronic Disease |
| D020969 | Disease Attributes |
| D010335 | Pathologic Processes |
| D013568 | Pathological Conditions, Signs and Symptoms |
| D005231 |
| Fatty Acids, Unsaturated |
| D005227 | Fatty Acids |
| D005395 | Fish Oils |
| D009821 | Oils |