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Aging, renal pathology (eg SLE, ADPKD), X-ray exposition and pharmacological treatments, especially previous strong immunosuppression, may negatively influence the ovarian reserve in childbearing age women. Anti-Müllerian hormone (AMH) is regarded as biomarker for ovarian reserve.
Every female with renal disease regularly menstruating that met exclusion criteria could have participated. The aim was to assess ovarian reserve in female patients with normal menstrual cycle and kidney disease, including kidney transplant recipients.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Patients with renal pathology treated with immunosuppressive drugs | Female in reproductive age suffering from renal disease that is or was previously treated with immunosuppressive drugs |
| |
| Patients with renal pathology without treatment | Control group |
| |
| Patients after renal transplantation taking immunosuppressive drugs | Female in reproductive age after renal transplantation taking immunosuppressive drugs |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| AMH level measurement | Diagnostic Test | AMH level measurement using ELISA test from blood samples |
|
| Measure | Description | Time Frame |
|---|---|---|
| To compare AMH levels between three groups | Serum AMH levels [ng/ml] measured using ELISA and compared between three groups | 1 day |
| Potential impact of X-ray exposition on ovarian reserve | Analysis of the impact of X-ray exposition [mSv] on AMH serum level [ng/ml] | 1 day |
| Potential impact of antiproliferative drugs on ovarian reserve | Analysis of the impact of antiproliferative drugs on AMH serum level [ng/ml] | 1 day |
| Potential impact of underlying kidney disease on ovarian reserve | Analysis of the impact of underlying kidney disease (including SLE) on AMH serum level [ng/ml] | 1 day |
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Inclusion Criteria:
Exclusion Criteria:
Female patients
Regularly menstruating female patients suffering from renal pathology or after renal transplantation
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| Name | Affiliation | Role |
|---|---|---|
| Julia Rasała, MD | Wroclaw Medical University | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Nephrology and Transplantation Clinic University Hospital in Wrocław | Wroclaw | 50-556 | Poland |
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