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end of normal study
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The aim of this protocol is to study the deleterious impact of adjuvant chemotherapy or neoadjuvant chemotherapy on ovarian reserve in young women suffering from breast cancer. A new relevant ovarian reserve marker, serum Anti-Mullerian Hormone, will be used in order to evaluate precisely the impact of chemotherapy on ovaries during chemotherapy administrations and after during follow-up (24 months). This strategy offers 2 main advantages : no modification of the traditional care of patients (treatment, organisation, follow up …) and use of a non invasive marker (serum). The final objective is to give precise information to patients on their future fertility after remission.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| young women with breast cancer |
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| Measure | Description | Time Frame |
|---|---|---|
| To evaluate the effects of adjuvant or neoadjuvant chemotherapy treatment on ovarian reserve for in situ breast cancer patients | Serum anti-Müllerian hormone concentration will be measured at each chemotherapy administration and 24 months follow-up after chemotherapy completion | 24 months |
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Inclusion Criteria:
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Young women with breast cancer
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| Name | Affiliation | Role |
|---|---|---|
| Paul Barrière, MD | Nantes University Hospital | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Institut Bergonié | Bordeaux | 33076 | France | |||
| Centre François BACLESSE |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 38957151 | Derived | Loubersac S, Chaillot M, Reignier A, Lefebvre T, Dezellus A, Colombel A, Barriere P, Masson D, Freour T. Serum androgen dynamics in young women aged 18-40 treated with chemotherapy for breast cancer: an observational, multicentric, prospective study in France. Hum Fertil (Camb). 2024 Dec;27(1):2350758. doi: 10.1080/14647273.2024.2350758. Epub 2024 Jul 3. |
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| ID | Term |
|---|---|
| D001943 | Breast Neoplasms |
| ID | Term |
|---|---|
| D009371 | Neoplasms by Site |
| D009369 | Neoplasms |
| D001941 | Breast Diseases |
| D012871 | Skin Diseases |
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Serum
| Caen |
| 14076 |
| France |
| Centre Jean Perrin | Clermont-Ferrand | 63011 | France |
| CRLC de Bourgogne Georges François Leclerc | Dijon | 21079 | France |
| Centre Oscar Lambret | Lille | 59000 | France |
| Centre de Lutte Contre le Cancer Léon Bérard | Lyon | 69373 | France |
| Centre Val d'Aurelle - Paul Lamarque | Montpellier | 34098 | France |
| Institut Curie | Paris | 75005 | France |
| Institut Jean Godinot | Reims | 51056 | France |
| Centre Eugène Marquis | Rennes | 35042 | France |
| Centre de Lutte Contre le Cancer Nantes Atlantique René Gauducheau | Saint-Herblain | 44805 | France |
| D017437 |
| Skin and Connective Tissue Diseases |