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To investigate the role of KATP channels on the cerebral hemodynamic in migraine patients.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| NN414 | Active Comparator | To investigate the role of NN414 compared with placebo in migraine patients. |
|
| Saline | Placebo Comparator | To investigate the role of NN414 compared with placebo in migraine patients. |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| NN414 | Drug | To investigate the role of NN414 on cerebral hemodynamic in migraine patients |
|
| Measure | Description | Time Frame |
|---|---|---|
| Occurrence and change of migraine attack | Occurrence of migraine according to international criteria | Before (-10 min) and after infusion (+2 hours) of NN414 compared with before and after infusion of saline |
| Measure | Description | Time Frame |
|---|---|---|
| Change in cerebral hemodynamic | Change on velocity of media cerebri artery. | Before (-10 min) and after infusion (+2 hours) of NN414 compared with before and after infusion of saline |
| Occurrence and change of headache |
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Criteria
Inclusion Criteria:
Exclusion Criteria:
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| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Danish Headache Center | Recruiting | Copenhagen | Capital Region | 2600 | Denmark |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 38729773 | Derived | Kokoti L, Al-Karagholi MA, Zhuang ZA, Amirguliyev S, Amin FM, Ashina M. Non-vascular ATP-sensitive potassium channel activation does not trigger migraine attacks: A randomized clinical trial. Cephalalgia. 2024 May;44(5):3331024241248211. doi: 10.1177/03331024241248211. |
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| ID | Term |
|---|---|
| D008881 | Migraine Disorders |
| ID | Term |
|---|---|
| D051270 | Headache Disorders, Primary |
| D020773 | Headache Disorders |
| D001927 | Brain Diseases |
| D002493 | Central Nervous System Diseases |
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| ID | Term |
|---|---|
| D012965 | Sodium Chloride |
| ID | Term |
|---|---|
| D002712 | Chlorides |
| D006851 | Hydrochloric Acid |
| D017606 | Chlorine Compounds |
| D007287 | Inorganic Chemicals |
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Quadruple
| Saline | Drug | To investigate the role of NN414 compared with saline cerebral hemodynamic in migraine patients. |
|
Occurrence of headache measured by numerical rating scale (NRS)
| Before (-10 min) and after infusion (+2 hours) of NN414 compared with before and after infusion of saline |
| Change of diameter of the artery | Change of diameter of superficial temporal artery and radial artery. The diameter will be measured by millimeter (mm). | Before (-10 min) and after infusion (+2 hours) of NN414 compared with before and after infusion of saline |
| D009422 | Nervous System Diseases |
| D017670 |
| Sodium Compounds |