Natriuretic Peptide's Headache Inducing Characteristics and Effects on the Cerebral Blood Flow

Mechanisms and Biological Markers During Headache Induced by Natriuretic Peptides

To investigate headache score and accompanying symptoms during and after infusion of the natriuretic peptides.

Inclusion Criteria:

• Healthy volunteers
• Aged 18-40
• 50-100 kg
• Fertile women must use safe contraceptives (IUD, oral contraceptives, surgical sterilisation and long lasting gestagen.

Exclusion Criteria:

• Tension type headache more than once/month
• Other primary headaches
• Daily medication except contraceptives
• Drug taken within 4 times the halflife for the specific drug except contraceptives
• Pregnant or lactating women
• Exposure to radiation within the last year
• Headache within the last 24 hours before start of trial
• Hypertension
• Hypotension
• Respiratory or cardiac disease