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In this evaluation, two versions of emails will be sent to Geisinger employees who have not been vaccinated against COVID-19. A delayed-contact control group will be emailed after a delay of at least two days. The researchers hypothesize that either of the emails - which use content informed by behavioral nudge theory - will lead to more COVID-19 vaccinations than the delayed-contact control group.
The researchers aim to evaluate the effectiveness of email reminders in promoting COVID-19 vaccinations among Geisinger employees. The project will compare two emails, which will vary in the subject line and email content. Both emails will test different approaches that draw from principles in behavioral science: social proof, reframing, and scarcity. Employees receiving these emails will be compared with employees in a delayed-contact group, who will not receive emails. Employees in the control group will later receive one of the emails.The responses to the emails will help determine the communications later sent to the control group.
All emails will ask recipients if they want to receive a COVID-19 vaccination. If they click on a hyperlink indicating yes, they will be forwarded to an online registration and scheduling homepage. If they click on a hyperlink indicating no, they will be forwarded to an online questionnaire surveying people about their main reason for declining the vaccine at this time. The questionnaire will automatically present information intended to assuage the specific concern that people endorse, followed by a hyperlink to the scheduling site.
The data will be analyzed with logistic regression models with the control group as the reference group, to compare the two email conditions versus the control group. This set of analyses will only be conducted for scheduling a vaccination appointment as opposed to email engagement outcomes (e.g., number of emails opened), which will not be applicable for the control group. A second set of logistic regression models predicting scheduling a vaccination appointment and email engagement will also be run, comparing the two email conditions against each other. The data will be examined two days later (to help decide which email to send to the delayed-control group) and four days later (when the policy for employee vaccination will change, making the content of the email irrelevant).
Update: The researchers looked at 3 days of data - as the emails to the delayed contact group were only sent at that time - and 4 days of data when the policy for employee vaccinations changed.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Delayed Contact | No Intervention | This group will not receive an email for at least two days. | |
| Social Proof | Experimental | This group will receive an email that points out that vaccine availability for employees will soon be limited. It also emphasizes how many fellow health care workers have been vaccinated. Seeing the behaviors of other people might encourage recipients to copy that behavior. |
|
| Reframing Side Effects and Adverse Reactions | Experimental | This group will receive an email that points out that vaccine availability for employees will soon be limited. It also addresses concerns about the side effects and adverse reactions of the vaccine. Due to potentially overblown concerns about the vaccine caused by the salience of side effects in the (social) media, the email attempts to reframe the risks by explicitly noting the small possibility of being affected by serious side effects and by contrasting that to the more severe effects of COVID-19. As a result of this reframing, recipients might recalibrate their perception of risks and benefits and opt for vaccination. |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Social Proof | Behavioral |
| ||
| Reframing |
| Measure | Description | Time Frame |
|---|---|---|
| Number of Employees Who Scheduled Vaccination Appointments After 3 Days | Binary variable of a scheduled vaccination appointment 3 days after the emails were sent | 3 days |
| Measure | Description | Time Frame |
|---|---|---|
| Number of Employees Who Opened Emails After 3 Days | Binary variable indicating whether the employee opened the email 3 days after the emails were sent | 3 days |
| Number of Employees Who Clicked Scheduling Links After 3 Days |
| Measure | Description | Time Frame |
|---|---|---|
| Number of Employees Who Scheduled Vaccination Appointments Until Policy Change (4 Days) | Binary variable of a scheduled vaccination appointment up to the end of January 19, when new distribution policies were enacted. | 4 days |
| Number of Employees Who Opened Emails Until Policy Change (4 Days) |
Inclusion Criteria:
Exclusion Criteria:
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| Name | Affiliation | Role |
|---|---|---|
| Michelle M Meyer, PhD | Geisinger Clinic | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Geisinger | Danville | Pennsylvania | 17822 | United States |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 34319359 | Derived | Santos HC, Goren A, Chabris CF, Meyer MN. Effect of Targeted Behavioral Science Messages on COVID-19 Vaccination Registration Among Employees of a Large Health System: A Randomized Trial. JAMA Netw Open. 2021 Jul 1;4(7):e2118702. doi: 10.1001/jamanetworkopen.2021.18702. |
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Data with no personally identifiable information will be made available to other researchers on the Open Science Framework for transparency. This will include the essential data and code needed to replicate the analysis that yielded reported findings.
The data will become available after publication of study results in a scientific journal and will be available as long as the Open Science Framework hosts the data.
The data on the Open Science Framework will be open to anyone requesting that information.
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| ID | Title | Description |
|---|---|---|
| FG000 | Delayed Contact | This group will not receive an email for at least two days. |
| FG001 | Social Proof | This group will receive an email that points out that vaccine availability for employees will soon be limited. It also emphasizes how many fellow health care workers have been vaccinated. Seeing the behaviors of other people might encourage recipients to copy that behavior. Social Proof: Email Scarcity Message: Email |
| FG002 | Reframing Side Effects and Adverse Reactions | This group will receive an email that points out that vaccine availability for employees will soon be limited. It also addresses concerns about the side effects and adverse reactions of the vaccine. Due to potentially overblown concerns about the vaccine caused by the salience of side effects in the (social) media, the email attempts to reframe the risks by explicitly noting the small possibility of being affected by serious side effects and by contrasting that to the more severe effects of COVID-19. As a result of this reframing, recipients might recalibrate their perception of risks and benefits and opt for vaccination. Reframing: Email Scarcity Message: Email |
| Title | Milestones | Reasons Not Completed | ||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Overall Study |
|
The baseline outcome measure was not applicable, since registration for vaccination was the outcome, and all participants were selected for not being registered.
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| ID | Title | Description |
|---|---|---|
| BG000 | Delayed Contact | This group will not receive an email for at least two days. |
| BG001 | Social Proof | This group will receive an email that points out that vaccine availability for employees will soon be limited. It also emphasizes how many fellow health care workers have been vaccinated. Seeing the behaviors of other people might encourage recipients to copy that behavior. Social Proof: Email Scarcity Message: Email |
| Units | Counts |
|---|---|
| Participants |
|
| Title | Description | Population Description | Parameter Type | Dispersion Type | Unit of Measure | Calculate Percentage | Denominator Units Selected | Denominators | Classes |
|---|---|---|---|---|---|---|---|---|---|
| Age, Categorical | Data was not collected. |
| Type | Title | Description | Population Description | Reporting Status | Anticipated Posting Date | Parameter Type | Dispersion Type | Unit of Measure | Calculate Percentage | Time Frame | Units Analyzed | Denominator Units Selected | Arm/Group Information | Denominators | Classes | Analyses | ||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Primary | Number of Employees Who Scheduled Vaccination Appointments After 3 Days | Binary variable of a scheduled vaccination appointment 3 days after the emails were sent | Posted | Count of Participants | Participants | 3 days |
|
No adverse events were evaluated.
We only had access to email engagement data and registration data, which was kept separate from clinical data.
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| ID | Title | Description | Deaths (Affected) | Deaths (At Risk) | Serious Events (Affected) | Serious Events (At Risk) | Other Events (Affected) | Other Events (At Risk) |
|---|---|---|---|---|---|---|---|---|
| EG000 | Delayed Contact | This group will not receive an email for at least two days. | 0 |
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In the original ClinicalTrials record, the researchers preregistered that the study would examine primary and secondary outcomes after two days. This was extended to about three days, which was the time when the delayed control group was emailed. This altered timing was dictated by when the organization's marketing department was ready to send emails to the delayed control group.
| Title | Organization | Phone | Extension | |
|---|---|---|---|---|
| Amir Goren, PhD | Geisinger Clinic | 5702144395 | agoren@geisinger.edu |
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| Type | Includes Protocol | Includes SAP | Includes ICF | Document Label | Document Date | Document Uploaded Date | Document File Name |
|---|---|---|---|---|---|---|---|
| Prot_SAP | Yes | Yes | No | Study Protocol and Statistical Analysis Plan | Jul 13, 2021 | Jul 13, 2021 | Prot_SAP_000.pdf |
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| ID | Term |
|---|---|
| D000072758 | Vaccination Refusal |
| D003142 | Communication |
| D001519 | Behavior |
| ID | Term |
|---|---|
| D016312 | Treatment Refusal |
| D000074822 | Treatment Adherence and Compliance |
| D015438 | Health Behavior |
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| ID | Term |
|---|---|
| D000088686 | Cognitive Restructuring |
| ID | Term |
|---|---|
| D015928 | Cognitive Behavioral Therapy |
| D001521 | Behavior Therapy |
| D011613 | Psychotherapy |
| D004191 | Behavioral Disciplines and Activities |
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1 x 3 design
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Participants will not know what group they are in. The relevant care provider (either their primary care provider or provider administering the vaccine) will not know about this study or assignment into groups.
| Behavioral |
|
| Scarcity Message | Behavioral |
|
Binary variable indicating whether the employee clicked the link to schedule a vaccination appointment 3 days after the emails were sent
| 3 days |
Binary variable indicating whether the employee opened the email up to the end of January 19, when new distribution policies were enacted. |
| 4 days |
| Number of Employees Who Clicked the Scheduling Link Until Policy Change (4 Days) | Binary variable indicating whether the employee clicked the link to schedule a vaccination appointment up to the end of January 19, when new distribution policies were enacted. | 4 days |
| BG002 | Reframing Side Effects and Adverse Reactions | This group will receive an email that points out that vaccine availability for employees will soon be limited. It also addresses concerns about the side effects and adverse reactions of the vaccine. Due to potentially overblown concerns about the vaccine caused by the salience of side effects in the (social) media, the email attempts to reframe the risks by explicitly noting the small possibility of being affected by serious side effects and by contrasting that to the more severe effects of COVID-19. As a result of this reframing, recipients might recalibrate their perception of risks and benefits and opt for vaccination. Reframing: Email Scarcity Message: Email |
| BG003 | Total | Total of all reporting groups |
| Participants |
|
| Sex: Female, Male | Data was not collected. | Count of Participants | Participants |
|
| Race and Ethnicity Not Collected | Race and Ethnicity were not collected from any participant. | Count of Participants | Participants |
|
| Region of Enrollment | Number | participants |
|
| OG002 | Reframing Side Effects and Adverse Reactions | This group will receive an email that points out that vaccine availability for employees will soon be limited. It also addresses concerns about the side effects and adverse reactions of the vaccine. Due to potentially overblown concerns about the vaccine caused by the salience of side effects in the (social) media, the email attempts to reframe the risks by explicitly noting the small possibility of being affected by serious side effects and by contrasting that to the more severe effects of COVID-19. As a result of this reframing, recipients might recalibrate their perception of risks and benefits and opt for vaccination. Reframing: Email Scarcity Message: Email |
|
|
|
| Secondary | Number of Employees Who Opened Emails After 3 Days | Binary variable indicating whether the employee opened the email 3 days after the emails were sent | Posted | Count of Participants | Participants | 3 days |
|
|
|
| Secondary | Number of Employees Who Clicked Scheduling Links After 3 Days | Binary variable indicating whether the employee clicked the link to schedule a vaccination appointment 3 days after the emails were sent | Posted | Count of Participants | Participants | 3 days |
|
|
|
| Other Pre-specified | Number of Employees Who Scheduled Vaccination Appointments Until Policy Change (4 Days) | Binary variable of a scheduled vaccination appointment up to the end of January 19, when new distribution policies were enacted. | Not Posted | 4 days | Participants |
| Other Pre-specified | Number of Employees Who Opened Emails Until Policy Change (4 Days) | Binary variable indicating whether the employee opened the email up to the end of January 19, when new distribution policies were enacted. | Not Posted | 4 days | Participants |
| Other Pre-specified | Number of Employees Who Clicked the Scheduling Link Until Policy Change (4 Days) | Binary variable indicating whether the employee clicked the link to schedule a vaccination appointment up to the end of January 19, when new distribution policies were enacted. | Not Posted | 4 days | Participants |
| 0 |
| 0 |
| 0 |
| 0 |
| 0 |
| EG001 | Social Proof | This group will receive an email that points out that vaccine availability for employees will soon be limited. It also emphasizes how many fellow health care workers have been vaccinated. Seeing the behaviors of other people might encourage recipients to copy that behavior. Social Proof: Email Scarcity Message: Email | 0 | 0 | 0 | 0 | 0 | 0 |
| EG002 | Reframing Side Effects and Adverse Reactions | This group will receive an email that points out that vaccine availability for employees will soon be limited. It also addresses concerns about the side effects and adverse reactions of the vaccine. Due to potentially overblown concerns about the vaccine caused by the salience of side effects in the (social) media, the email attempts to reframe the risks by explicitly noting the small possibility of being affected by serious side effects and by contrasting that to the more severe effects of COVID-19. As a result of this reframing, recipients might recalibrate their perception of risks and benefits and opt for vaccination. Reframing: Email Scarcity Message: Email | 0 | 0 | 0 | 0 | 0 | 0 |
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