Aim of the work Impact of serum vit D level in SLE patients with COVID-19 disease on severity of infection, duration of COVID-19 disease course, fatigue development as a complication for both SLE and COVID-19 and assess impact of prior chloroquine on COVID-19 disease outcomes Patients and methods 38 SLE patients previously diagnosed and on different lines of lupus management. Participants were presented to chest outpatient clinic and emergency hospital, Mansoura University with manifestation suggesting COVID-19 infection. Serum vit D was measured in serum by ELISA.

Primary objective: assess the impact of serum vit D level in SLE patients with COVID-19 disease on severity of infection and pandemic treatment outcome.

Secondary objectives:

• Effect of serum vit D level in SLE patients on duration of COVID-19 disease course and fatigue development as a complication for both SLE and COVID-19
• Impact of prior chloroquine on COVID-19 disease outcomes
• Correlation of serum vit D level with different laboratory investigations at time of COVID-19 outbreak

Inclusion Criteria:

• - SLE patients previously diagnosed
• Patients are not suffering from malignancies.
• Patients have no organ failure nor uncontrolled medical illness.
• Recent COVID-19 infection

Exclusion Criteria:

• - Pregnant, lactating females
• Concurrent malignancies
• Patients with other autoimmune disease

SLE patients infected with COVID-19