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To study the effect of acute normobaric hypoxia during exercise in patients with pulmonary hypertension with/without Sildenafil
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Normobaric hypoxia (FiO2 15%) | Experimental | Inhalation of deoxygenated air through an altitude simulator ("Altitrainer"), for approx. 1/2 hour given by a facemask, first at rest and then during exercise. |
|
| Placebo-ambient air (FiO2 21%) | Sham Comparator | Inhalation of room air through an altitude simulator ("Altitrainer"), for approx. 1/2 hour given by a facemask, first at rest and then during exercise. |
|
| Normobaric hypoxia (FiO2 15%) under Sildenafil | Experimental | Inhalation of deoxygenated air through an altitude simulator ("Altitrainer"), for approx. 1/2 hour given by a facemask, first at rest and then during exercise. |
|
| Placebo-ambient air (FiO2 21%) under Sildenafil | Active Comparator | Inhalation of room air through an altitude simulator ("Altitrainer"), for approx. 1/2 hour given by a facemask, first at rest and then during exercise. |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Normobaric hypoxia (FiO2 15%) | Other | Inhalation of deoxygenated air through an altitude simulator ("Altitrainer"), for approx. 1/2 hour given by a facemask, first at rest and then during exercise. |
| Measure | Description | Time Frame |
|---|---|---|
| mean pulmonary artery pressure (mPAP) / cardiac output (CO) | Difference in mPAP/CO during exercise between tests under normoxia/hypoxia with/without Sildenafil | 4 hours |
| Measure | Description | Time Frame |
|---|---|---|
| Differences in pulmonary arterial pressure | Differences in pulmonary arterial pressure at rest and during exercise under normoxia/hypoxia with/without Sildenafil | 4 hours |
| Differences in cardiac output |
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Inclusion Criteria:
Exclusion Criteria:
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| Name | Affiliation | Role |
|---|---|---|
| Silvia Ulrich, Prof. Dr. | UniversityHospital Zurich, Department of Pulmonology | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| University Hospital of Zurich | Zurich | 8091 | Switzerland |
We will share individual participant data after publication of the manuscript. The decision about the platform is ongoing.
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After publication of the manuscript.
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| Placebo-ambient air (FiO2 21%) | Other | Inhalation of room air through an altitude simulator ("Altitrainer"), for approx. 1/2 hour given by a facemask, first at rest and then during exercise. |
|
| Normobaric hypoxia (FiO2 15%) under Sildenafil | Other | Inhalation of deoxygenated air through an altitude simulator ("Altitrainer"), for approx. 1/2 hour given by a facemask, first at rest and then during exercise. |
|
| Placebo-ambient air (FiO2 21%) under Sildenafil | Other | Inhalation of room air through an altitude simulator ("Altitrainer"), for approx. 1/2 hour given by a facemask, first at rest and then during exercise. |
|
Differences in cardiac output at rest and during exercise under normoxia/hypoxia with/without Sildenafil
| 4 hours |
| Differences in pulmonary vascular resistance | Differences in pulmonary vascular resistance at rest and during exercise under normoxia/hypoxia with/without Sildenafil | 4 hours |
| Differences in pulmonary artery wedge pressure | Differences in pulmonary artery wedge pressure at rest and during exercise under normoxia/hypoxia with/without Sildenafil | 4 hours |
| Differences in right atrial pressure | Differences in right atrial pressure at rest and during exercise under normoxia/hypoxia with/without Sildenafil | 4 hours |
| Differences in mixed venous oxygen saturation | Differences in mixed venous oxygen saturation at rest and during exercise, under normoxia/hypoxia with/without Sildenafil | 4 hours |
| Differences in heart rate | Differences in heart rate at rest and during exercise, under normoxia/hypoxia with/without Sildenafil | 4 hours |
| Differences in blood pressure | Differences in blood pressure at rest and during exercise, under normoxia/hypoxia with/without Sildenafil | 4 hours |
| Differences in oxygen saturation | Differences in oxygen saturation at rest and during exercise, under normoxia/hypoxia with/without Sildenafil | 4 hours |
| Differences in arterial blood gases | Differences in arterial blood gases at rest and during exercise under normoxia/hypoxia with/without Sildenafil | 4 hours |
| Differences in mixed venous blood gases | Differences in mixed venous blood gases at rest and during exercise under normoxia/hypoxia with/without Sildenafil | 4 hours |
| Differences in cerebral tissue oxygenation | Differences in cerebral tissue oxygenation at rest and during exercise, with normoxia/hypoxia with/without Sildenafil | 4 hours |
| Differences in muscle tissue oxygenation | Differences in muscle tissue oxygenation at rest and during exercise, with normoxia/hypoxia with/without Sildenafil | 4 hours |
| Differences in symptoms (Borg dyspnoea) | Differences in symptoms (Borg dyspnoea) at rest and during exercise under normoxia/hypoxia with/without Sildenafil | 4 hours |
| Differences in symptoms (Borg leg effort) | Differences in symptoms (Borg leg effort) at rest and during exercise under normoxia/hypoxia with/without Sildenafil | 4 hours |
| ID | Term |
|---|---|
| D006976 | Hypertension, Pulmonary |
| D000860 | Hypoxia |
| D009043 | Motor Activity |
| ID | Term |
|---|---|
| D008171 | Lung Diseases |
| D012140 | Respiratory Tract Diseases |
| D006973 | Hypertension |
| D014652 | Vascular Diseases |
| D002318 | Cardiovascular Diseases |
| D012818 | Signs and Symptoms, Respiratory |
| D012816 | Signs and Symptoms |
| D013568 | Pathological Conditions, Signs and Symptoms |
| D001519 | Behavior |
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