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N=104 juvenile idiopathic arthritis patients diagnosed after ILAR criteria with unilateral persistent knee arthritis. They will be randomly assigned into two groups; group 1 will receive genicular nerve block, group 2 intra-articular triamcinolone. Both groups will be examined by SOLAR ultrasound scoring system, Visual analogue scale and Lysholm score at 0, 2 and 12 weeks. A semi-quantitative score will be used to assess tenderness and swelling at the same intervals.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Active genicular nerve block group | Active Comparator | group 1 will receive genicular nerve block. The injection and US examination will be done by two experienced sonographers. They were blinded to clinical data. Patients will also be blinded for the injected substance. Each point will be injected with 2 ml of Lidocaine hydrochloride 2 % (Xylocaine, Astrazeneca). The injection will be done using the 3 point technique (superior medial, superior lateral, and inferior medial genicular nerves). |
|
| intra-articular steroid injection group | Other | while group 2 received intra-articular triamcinolone under ultrasound guidance and through injecting the supra-patellar bursa. |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| genicular nerve block | Drug | nerve block of the genicular nerve at 3 points around the inflamed knee using ultrasound. |
|
| Measure | Description | Time Frame |
|---|---|---|
| Change in SOLAR score over time | score to assess ultrasound parameters of the knee including power doppler and grey scale measures | Baseline, 2 weeks and 12 weeks |
| Change in visual analogue scale over time | a graded score for pain evaluation filled by the patient graded from 0 to 10 | Baseline, 2 weeks and 12 weeks |
| Change in Lysholm score over time | a score to assess knee function. This questionnaire has 8 domains. A score between 95 and 100 means excellent functional performance, good 84-94, fair 65-83 and poor <64 | Baseline, 2 weeks and 12 weeks |
| Change in semiquantitative score for swelling and tenderness over time | A score graded from 0 to 3; score 0 means no swelling nor tenderness and 3 means maximum swelling and tenderness | Baseline, 2 weeks and 12 weeks |
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Inclusion Criteria:
Exclusion Criteria:
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| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Sohag university | Sohag | 82749 | Egypt |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 36197647 | Derived | Radwan A, Ohrndorf S, Aly H, Hamed M, Khalifa A, Elsaman AM. Genicular nerve block in juvenile idiopathic arthritis: a randomized clinical trial. Clin Rheumatol. 2023 Mar;42(3):879-888. doi: 10.1007/s10067-022-06389-4. Epub 2022 Oct 5. |
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| ID | Term |
|---|---|
| D001171 | Arthritis, Juvenile |
| ID | Term |
|---|---|
| D001168 | Arthritis |
| D007592 | Joint Diseases |
| D009140 | Musculoskeletal Diseases |
| D012216 | Rheumatic Diseases |
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| ID | Term |
|---|---|
| D013256 | Steroids |
| ID | Term |
|---|---|
| D000072473 | Fused-Ring Compounds |
| D011083 | Polycyclic Compounds |
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| intra-articular steroid injection | Drug | Triamcinilone injection into the knee joint under ultrasound guidance. |
|
| D003240 |
| Connective Tissue Diseases |
| D017437 | Skin and Connective Tissue Diseases |
| D001327 | Autoimmune Diseases |
| D007154 | Immune System Diseases |