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N=64 RA patients either early or established disease diagnosed after ACR/EULAR criteria 2010 with unilateral persistent knee arthritis. They were randomly assigned into two groups; group 1 received genicular nerve block, group 2 intra-articular triamcinolone. Both groups were examined by SOLAR scoring system, Visual analogue scale (VAS) and Lysholm score at 0, 2 and 12 weeks. A semi-quantitative score was used to assess tenderness and swelling at the same intervals.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Nerve block group | Active Comparator | 3 point genicular nerve block under ultrasound guidance. half ml of Bupivacaine hydrochloride 0.5% (Marcaine, Pfizer) was injected in each point. |
|
| intra-articular steroid injection | Other | 1 mL of triamcinolone 40 milligrams (Kenacort, Bristol Myers Squip) was injected intraarticular. |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Bupivacaine hydrochloride 0.5% (Marcaine, Pfizer) | Drug | 3 point genicular nerve block |
|
| Measure | Description | Time Frame |
|---|---|---|
| Pain changes by VAS | 0 means no pain and 10 means the most severe pain | at 0 time after 2 weeks and after 12 weeks |
| SOLAR score for inflammation changes by ultrasound | 0 means normal and 27 means the worst possible inflammation | at 0 time after 2 weeks and after 12 weeks |
| Lysholm score for change in knee function | 100 means the best performance and 0 means complete loss of function | at 0 time after 2 weeks and after 12 weeks |
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Inclusion Criteria:
Exclusion Criteria:
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| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Minia university | Minya | 82749 | Egypt |
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| ID | Term |
|---|---|
| D010146 | Pain |
| D007249 | Inflammation |
| ID | Term |
|---|---|
| D009461 | Neurologic Manifestations |
| D012816 | Signs and Symptoms |
| D013568 | Pathological Conditions, Signs and Symptoms |
| D010335 | Pathologic Processes |
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| ID | Term |
|---|---|
| D002045 | Bupivacaine |
| D014221 | Triamcinolone |
| ID | Term |
|---|---|
| D000813 | Anilides |
| D000577 | Amides |
| D009930 | Organic Chemicals |
| D000814 | Aniline Compounds |
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Group received nerve block and another group received steroid
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The participants does not know the nature of the injected material. Syringe was colored to cover it
| triamcinolone 40 milligrams (Kenacort, Bristol Myers Squip) | Drug | intra-articular injection of triamcinilone |
|
| D000588 |
| Amines |
| D011245 | Pregnadienes |
| D011278 | Pregnanes |
| D013256 | Steroids |
| D000072473 | Fused-Ring Compounds |
| D011083 | Polycyclic Compounds |
| D013259 | Steroids, Fluorinated |