Evaluation of Lycopene in the Treatment of Erosive Oral Lichen Planus

Evaluation of Lycopene in the Treatment of Erosive Oral Lichen Planus (A Randomized Clinical Trial)

The aim of this study was to evaluate the effect of oral lycopene and systemic steroids in the treatment of erosive oral lichen planus and compare between the two therapeutic modalities.

Twenty erosive lichen planus patients were recruited and randomly assigned in one of two groups, the test (lycopene) and control (corticosteroids) group.

Inclusion Criteria:

• Erosive oral lichen planus patients with severe and extensive painful erythematous, erosive and/ or ulcerative lesions who are in need for systemic corticosteroid therapy

Exclusion Criteria:

• Pregnant females and smokers.
• Patients suggestive of having lichenoid contact/drug reactions.
• Patients suffering from any systemic disease as diabetes, liver disease, renal disease, any other autoimmune or collagen disease.
• Lesions showing histological features of dysplasia.
• Patients with skin lichen planus lesions.