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To study the effect of platelet-rich plasma concentrate on marginal bone loss and bone mineral density in immediate implant placement through CBCT.
12 subjects were equally categorized into two groups. Group, I was the control group; whereas, the subjects in Group II received Platelet Rich Plasma (PRP) therapy. All subjects were given a standard treatment with single implant system. Inserted implants were analyzed through Cone Beam Computerized Tomography (CBCT). Records were registered at the baseline, at 12th week before functional loading and 26th week after functional loading.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Control Group | No Intervention | Dental implant was placed in these patients following full protocol of immediate implant placement. | |
| PRP Group | Experimental | In this group Platelet Rich Plasma (PRP) was injected in soft tissue over surgical site. |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| PRP injection | Biological | PRP was prepared using patient's blood and mixed with saline or mixture of calcium chloride and thrombin to form a liquid solution; in order to inject at the surgical site after placement of implant. |
| Measure | Description | Time Frame |
|---|---|---|
| Measurement of bone loss at baseline (12 weeks) and later at 26weeks | Measurement at mesial in mm | Baseline -before functional loading at 12 weeks & at 26 weeks- after functional loading to assess changes in marginal bone loss in sagittal view using CBCT |
| Measure | Description | Time Frame |
|---|---|---|
| Measurement of bone loss at baseline (12 weeks) and later at 26weeks | Measurement at distal in mm | Baseline -before functional loading at 12 weeks & at 26 weeks- after functional loading to assess changes in marginal bone loss in sagittal view using CBCT |
| Measure | Description | Time Frame |
|---|---|---|
| Bone Mineral Density | Measurement in Hounsfield number | Baseline -before functional loading at 12 weeks & at 26 weeks- after functional loading to assess changes in marginal bone loss in sagittal view using CBCT |
Inclusion Criteria:
Exclusion Criteria:
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| Name | Affiliation | Role |
|---|---|---|
| Aleshba Saba khan, BDS; FCPS | Institute of Dentistry; CMH Lahore Medical College | Principal Investigator |
| Naauman Zaheer, BDS; PhD | Institute of Dentistry; CMH Lahore Medical College | Principal Investigator |
| Abdul Mueed Zaigham, BDS; FCPS | Institute of Dentistry; CMH Lahore Medical College | Study Chair |
| Maliha Shahbaz, BDS; MPhil | Oral Biology Department; Rashid Latif Dental College, Lahore | Study Director |
| Usman Zaheer, BDS; FCPS | Lahore Medical & Dental College | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Institute of Dentistry; CMH Lahore Medical College | Lahore | Punjab Province | Pakistan |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 26023636 | Result | Boora P, Rathee M, Bhoria M. Effect of Platelet Rich Fibrin (PRF) on Peri-implant Soft Tissue and Crestal Bone in One-Stage Implant Placement: A Randomized Controlled Trial. J Clin Diagn Res. 2015 Apr;9(4):ZC18-21. doi: 10.7860/JCDR/2015/12636.5788. Epub 2015 Apr 1. | |
| 33791377 | Derived | Khan AS, Zaheer N, Zaigham AM, Shahbaz M, Zaheer U, Alam MK. Effect of Platelet-Rich Plasma on Bone Healing in Immediate Implants Analyzed by Cone Beam Computerized Tomography: A Randomized Controlled Trial. Biomed Res Int. 2021 Mar 13;2021:6685991. doi: 10.1155/2021/6685991. eCollection 2021. |
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| ID | Term |
|---|---|
| D016301 | Alveolar Bone Loss |
| ID | Term |
|---|---|
| D001862 | Bone Resorption |
| D001847 | Bone Diseases |
| D009140 | Musculoskeletal Diseases |
| D055093 | Periodontal Atrophy |
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|
| Automated blood cell separator to extract PRP | Device | Blood was withdrawn from antecubital vein and mixed with anticoagulant. Blood sample was then centrifuged to obtain platelet rich plasma which was injected at surgical site after implant placement. |
|
|
| D010510 |
| Periodontal Diseases |
| D009059 | Mouth Diseases |
| D009057 | Stomatognathic Diseases |