Platelet Rich Fibrin and Concentrated Growth Factors on Osseointegration of Immediate Implants

A Comparative Study Between the Effect of Platelet-rich Fibrin and Concentrated Growth Factors on Osseointegration of Immediate Implants (a Randomized Clinical Trial)

This study will involve 14 patients with mandibular premolars indicated for extraction and immediate replacement. The patients will be randomly allocated into two groups and each patient will receive one implant. In Group A, a CGF membrane will be laid in the implant cavity. While in Group B, a PRF membrane will be laid in the implant cavity. Bone graft material will be applied to fill the empty parts of the socket.

Resonance frequency measurement will be done using the OSTELL device intraoperatively, at the 1st week and after 3 months. Cone-beam computed tomography will be done preoperatively, immediately following surgery, and after 3 months

Inclusion Criteria:

• Cooperative patients with good oral hygiene.
• Patients having a history of mandibular premolars indicated for extraction and immediate replacement.

Exclusion Criteria:

• Heavy smokers.
• Parafunctional occlusal habits.
• Uncontrolled diabetes.
• History of chemotherapy or radiotherapy.
• Hematological disorders that prevent either implantation or centrifugation.
• Pregnancy.
• The nee¬d for additional augmentation or previous augmentation of the same region.
• Chronic periapical pathology