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The normal architecture of the alveolar process is altered by periodontitis, which also causes the loss of alveolar bone surrounding the teeth. Untreated periodontitis may cause teeth to become mobile and leads to loss of teeth.
In such cases, one of the treatment modalities is extraction of the tooth and placement of immediate implant which reduces the waiting period. And due to the resorption of alveolar ridge the bone graft will be used along with T-PRF and PRF.
So this study aims at the placement of immediate implants along with T-PRF with bone graft and PRF with bone graft.
Dental implants have become more common treatment for replacing missing teeth and aim to improve chewing efficiency, physical health and esthetic. And their will be resorption of alveolar process due to periodontitis . In such compromised cases, to achieve bone augmentation around immediately placed implants a new modality of using platelet rich fibrin (PRF) along with graft material has gained considerable interest.
Successful clinical results have been reported with L-PRF, but some physicians worry about a possible health hazard with glass-evacuated blood collection tubes with silica activators. O'Connell described the unavoidable silica contact. The silica particles in the tube, although dense enough to sediment with the red blood cells, are small enough for a fraction to remain colloidally suspended in the buffy coat, fibrin, and platelet-poor plasma layers therefore, these particles might reach the patient when the product is used for treatment.
Recently use of titanium tubes in the preparation of PRF showed more polymerized fibrin formation with longer resorption in tissues as titanium seems to be more effective in activating platelets than silica and also eliminates the possible silica contamination.
The use of T-PRF(Titanium PRF) along with xenograft creates a block graft with high concentrated growth factors, platelets and leucocytes which enhance development of bone and eliminates the possible silica contamination.
Hence, the aim of the study is to compare the effectiveness of T-PRF with xenograft [DMBM] and PRF with xenograft [DMBM] around immediate implants.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| in 10 sites immediate implant will be placed along with T-PRF and xenograft | Experimental | Immediate implant is placed along with T-PRF and xenograft. |
|
| in 10 sites immediate implants will be placed with PRF and xenograft | Active Comparator | Immediate implant is placed along with PRF and xenograft as control |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Immediate implant surgery with T-PRF and xenograft | Procedure | A mucoperiosteal flap will be raised and atraumatic extraction will be done. An immediate implant with T-PRF and xenograft will be placed according to the standard protocol. The surgical wound closure will be coapted with mattress and single interrupted sutures |
| Measure | Description | Time Frame |
|---|---|---|
| Marginal Bone Level Using RVG and Grid. | Marginal bone level measured . | Baseline , 3 months , 9 months |
| Soft tissue healing | Soft tissue healing will be assessed using Wachtel-et-al 2009 classification | Baseline ,3 months , 9 months |
| Bone fill using RVG with grid | Measuring the Bone fill by formula Linear bone growth/depth of original bone defect | 3 months , 9 months |
| Bone dimensions using CBCT | Extent of bone dimensions is measured through CBCT | 9 months |
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Inclusion Criteria:
Exclusion Criteria:
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| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Krishnadevaraya college of dental sciences | Bangalore | Karnataka | 562157 | India |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 22951383 | Background | Tunali M, Ozdemir H, Kucukodaci Z, Akman S, Firatli E. In vivo evaluation of titanium-prepared platelet-rich fibrin (T-PRF): a new platelet concentrate. Br J Oral Maxillofac Surg. 2013 Jul;51(5):438-43. doi: 10.1016/j.bjoms.2012.08.003. Epub 2012 Aug 28. |
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Individual Participant Data will not be shared with other researchers.
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|
| Immediate implant surgery with PRF and xenograft | Procedure | A mucoperiosteal flap will be raised and atraumatic extraction will be done. An immediate implant with PRF and xenograft will be placed according to the standard protocol . The surgical wound closure will be coapted with mattress and single interrupted sutures |
|
| ID | Term |
|---|---|
| D014183 | Transplantation, Heterologous |
| D056690 | Prolactin-Releasing Hormone |
| ID | Term |
|---|---|
| D014180 | Transplantation |
| D013514 | Surgical Procedures, Operative |
| D007028 | Hypothalamic Hormones |
| D036361 | Peptide Hormones |
| D006728 | Hormones |
| D006730 | Hormones, Hormone Substitutes, and Hormone Antagonists |
| D009479 | Neuropeptides |
| D010455 | Peptides |
| D000602 | Amino Acids, Peptides, and Proteins |
| D009419 | Nerve Tissue Proteins |
| D011506 | Proteins |
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