Impact of Adipose Tissue in COVID-19

Impact of Adipose Tissue in COVID-19 : From Pathophysiology to Therapeutic Perspectives

Overweight or obese patients are particularly exposed to severe forms of COVID-19. Few data suggest that adipose tissue infected with SARS-CoV-2 could be involved in the onset of the cytokine storm seen in severe forms of COVID-19. The aim of this study is to determine the pathogenesis of SARS-CoV-2-infection of adipose tissue. In particular the investigators will study how this virus enters the adipocyte and how it modulates metabolism and inflammation in the adipose tissue. From these data, the investigators hope to determine at the adipose tissue level, original therapeutic targets to modulate the effects of SARS-CoV-2 at the systemic level.

Inclusion Criteria:

• Age greater than or equal to 18 years
• All patients who are obese or overweight (> 25 kg/m2) or non-obese (< or = 25 kg/m2) operated for abdominal vascular surgery
• Beneficiary or entitled to a social security scheme (except AME)

Exclusion Criteria:

• Pregnant or breastfeeding woman
• Patient refusal
• Patient deprived of liberty or subject to a legal protection measure (guardianship, curatorship)