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Resident cells of human adipose tissue express ACE2 and DPP4, receptors for SARS-Cov2. The hypothesis is that the virus may enter and spread in fat depots.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| patients with Covid-19 | Experimental |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| biopsies of subcutaneous adipose tissue | Procedure | Two 4mm punch biopsies of subcutaneous abdominal or thight adipose tissue |
|
| Measure | Description | Time Frame |
|---|---|---|
| The presence of SARS-CoV2 in adipose tissue of Covid19 patients | RT-qPCR for SARS-Cov-2 from RNAs and by immunodetection | Day 0 |
| Measure | Description | Time Frame |
|---|---|---|
| The expression of inflammatory cytokines in adipose tissue of Covid19 patients | RT-qPCR for IL6 | Day 0 |
| The expression of inflammatory cytokines in adipose tissue of Covid19 patients | RT-qPCR for IL1 |
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Inclusion Criteria:
Exclusion Criteria:
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| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| CHU de Nice | Nice | 06000 | France |
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| Day 0 |
| The expression of inflammatory cytokines in adipose tissue of Covid19 patients | RT-qPCR for TNFa | Day 0 |