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This study will involve collection of pseudonymized data from hospital-based data reporting at multiple international sites. Collating data from a large volume of patients with COVID-19 admitted in ICU across multiple international sites will enable investigation of whether obesity is a risk factor for complicated from of SARS-CoV-2 in adult patients and whether this association is independent of other cardiometabolic risk factors.
The COVID-19 pandemic is characterized by a high frequency of patients with severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2), who often require invasive mechanical ventilation (IMV). Body mass index (BMI) was however rarely mentioned in early clinical reports.
Disease severity gradually increased with body mass index (BMI) categories among patients admitted in intensive care unit (ICU) for severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2), the need for invasive mechanical ventilation (IMV), reaching 85% in patients with class II or III obesity ( BMI > 35 kg/m2).
In summary, there is an urgent need for more evidence on the specific role played by obesity in the development of COVID-19 complications, and more particularly of severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2)
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| BMI SARS-CoV-2 | Patients admitted to Intensive Care Unit with SARS-CoV-2 |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Patients admitted to Intensive Care Unit with SARS-CoV2 | Other | Patients admitted to Intensive Care Unit with SARS-CoV2 |
|
| Measure | Description | Time Frame |
|---|---|---|
| Relationship between body mass index (BMI) and SARS-CoV-2 | The primary objective of this study is to investigate the relationship between obesity, as determined by body mass index (BMI), and severe pneumonia, as defined by the need of invasive mechanical ventilation ( IMV), among patient admitted in ICU for SARS-CoV-2, across multiple centers, in multiple countries. | 3 months |
| Measure | Description | Time Frame |
|---|---|---|
| Associations between BMI and outcomes is independent of the known cardiometabolic risk factors | Investigate whether the associations between BMI and outcomes is independent of the known cardiometabolic risk factors, hypertension, diabetes, dyslipidemia, and current smoking. | 3 months |
| Investigate the modifying effects of age and sex on the associations between BMI and outcome: Invasive mechanical ventilation |
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Inclusion Criteria:
Exclusion Criteria:
-There are no exclusion criteria
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Adult patients admitted to Intensive Care Unit for SARS-CoV-2
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| Name | Affiliation | Role |
|---|---|---|
| Francois Pattou, MD | Centre Hospitalier Régional & Universitaire de Lille (CHRU) | Study Director |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Centre Hospitalier Régional & Universitaire de Lille (CHRU) | Lille | 59100 | France |
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| ID | Term |
|---|---|
| D009765 | Obesity |
| ID | Term |
|---|---|
| D050177 | Overweight |
| D044343 | Overnutrition |
| D009748 | Nutrition Disorders |
| D009750 | Nutritional and Metabolic Diseases |
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Investigate the modifying effects of age and sex on the associations between BMI and outcome: Invasive mechanical ventilation |
| 3 months |
| Investigate the modifying effects of age and sex on the associations between BMI and outcome: mortality | Investigate the modifying effects of age and sex on the associations between BMI and outcome: mortality | 3 months |
| D001835 |
| Body Weight |
| D012816 | Signs and Symptoms |
| D013568 | Pathological Conditions, Signs and Symptoms |