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Disproportionate impact of COVID-19 in patients with obesity is now well established.
Obesity is associated with severe forms of COVID-19 and may be a risk factor of intensive care unit (ICU) admission. Obesity is associated with COVID-19 related hospital death in a large United Kingdom cohort study. However, there is a gap of knowledge on assessment of outcomes such as severity of Acute Respiratory Distress syndrome (ARDS), duration of hospitalisation and mortality in ICU. Moreover, an obesity survival paradox has been observed in patients with ARDS. This raises the question whether the obesity paradox has been broken by COVID-19.
The investigators aim to explore risk factors of in-ICU death for patient with COVID-19, including obesity and other chronic diseases and to describe the clinical course and outcomes, including the management of acute respiratory failure and other intensive care management.
The investigators aim to report ICU mortality for patients according to BMI category and to describe the detailed ICU clinical course of illness :
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Normal weight | BMI < 25 kg/m2 | ||
| Overweight | BMI : 25 - 29.9 kg/m2 | ||
| Moderate obesity | BMI : 30 - 39.9 kg/m2 | ||
| Severe obesity | BMI : > or = 40 kg/m2 |
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| Measure | Description | Time Frame |
|---|---|---|
| ICU mortality | number of fatal cases | through study completion, an average of 14 days |
| Measure | Description | Time Frame |
|---|---|---|
| Invasive mechanical ventilation | number of patients with invasive mechanical ventilation | through study completion, an average of 14 days |
| In-hospital mortality | number of fatal cases |
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Inclusion Criteria:
Exclusion Criteria:
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Critically ill patients admitted to ICUs of the University Hospital during the first Covid -19 wave in Nancy, Région Grand Est, France
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| Name | Affiliation | Role |
|---|---|---|
| Olivier Ziegler, PU-PH | CHRU of Nancy | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Centre hospitalo-universitaire régional de Nancy | Vandœuvre-lès-Nancy | 54511 | France |
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| ID | Term |
|---|---|
| D045169 | Severe Acute Respiratory Syndrome |
| D009765 | Obesity |
| D000086382 | COVID-19 |
| D012128 | Respiratory Distress Syndrome |
| ID | Term |
|---|---|
| D012141 | Respiratory Tract Infections |
| D007239 | Infections |
| D018352 | Coronavirus Infections |
| D003333 | Coronaviridae Infections |
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| through study completion, an average of 21 days |
| D030341 | Nidovirales Infections |
| D012327 | RNA Virus Infections |
| D014777 | Virus Diseases |
| D012140 | Respiratory Tract Diseases |
| D050177 | Overweight |
| D044343 | Overnutrition |
| D009748 | Nutrition Disorders |
| D009750 | Nutritional and Metabolic Diseases |
| D001835 | Body Weight |
| D012816 | Signs and Symptoms |
| D013568 | Pathological Conditions, Signs and Symptoms |
| D011024 | Pneumonia, Viral |
| D011014 | Pneumonia |
| D008171 | Lung Diseases |
| D012120 | Respiration Disorders |