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Investigate the differences in activation of brain networks during performing functional tasks for children with attention deficit hyperactivity disorder with developmental delays and typical development
A total of 12 children with attention deficit hyperactivity disorder with developmental delays and12 children with typical development will be enrolled.
The following evaluations will be evaluated by the investigator who is blinded to the group's classification.
Working task-related functions, such as Beery-Buktenica Visual-Motor Integration, Sensory Profile, the Chinese version of Swanson, Nolan and Pelham version IV, and Chinese version of Wechsler Intelligence Scale for Children-IV)
Non-working memory-related functions, such as Pediatric Outcome Data Collection Instrument (PODCI), Child Health Questionnaire- Parent Form (CHQ-PF 28), Pediatric Quality of Life Inventory (PedsQL), and physical function (10 meters normal and fast walking, stair ascent, stair descent, and 5 times chair rising and timed up and go test)
All participants will be investigated by magnetoencephalography and eye-tracking system to identify the difference of brain network activation during resting and performing tasks and between-group differences.
Brain magnetic resonance image study will be performed for matching of brain localization.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Children with attention deficit hyperactivity disorder with developmental delays | Children with attention deficit hyperactivity disorder with developmental delays |
| |
| Children with typical development | Children with typical development |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Brain networks activity | Other | The brain network activity under different conditions will be evaluated by magnetoencephalography, including resting, listen to different types of music, watch different types of videos, and interacting with cognitive stimulation conditions. |
| Measure | Description | Time Frame |
|---|---|---|
| Brain network activity by magnetoencephalograph | magnetoencephalography by different types of music | measure simultaneous brain activity by different types of music through study completion, up to 6 minutes |
| Brain network activity by magnetoencephalography | magnetoencephalography by different types of videos | measure simultaneous brain activity by different types of videos through study completion, up to 10.5 minutes |
| Brain network activity by magnetoencephalography | magnetoencephalography by different types of interactive cognitive stimulation | measure simultaneous brain activity by different types of interactive cognitive stimulation through study completion, up to 5 minutes |
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| Measure | Description | Time Frame |
|---|---|---|
| Beery-Buktenica Visual-Motor Integration | assess visual motor function | before magnetoencephalography examination |
| Sensory Profile Questionnaire | assess sensory integration,15 to 85, higher scores mean a better outcome |
Inclusion Criteria:
Exclusion Criteria:
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Children diagnosed with attention deficit hyperactivity disorder with developmental delays, aged 4 to 10; and age-sex matched children with typical development
| Name | Role | Phone | Extension | |
|---|---|---|---|---|
| Ru-Lan Hsieh, MD | Contact | 886228332211 | 2531 | M001052@ms.skh.org.tw |
| Ru-Lan Hsieh, MD | Contact | 886228662211 | 2531 | M001052@ms.skh.org.tw |
| Name | Affiliation | Role |
|---|---|---|
| Ru-Lan Ru-Lan, MD | Shin Kong Wu Ho-Su Memorial Hospital | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Shin Kong Wu Ho-Su Memorial Hospital | Taipei | 111-01 | Taiwan |
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| ID | Term |
|---|---|
| D001289 | Attention Deficit Disorder with Hyperactivity |
| D007859 | Learning Disabilities |
| ID | Term |
|---|---|
| D019958 | Attention Deficit and Disruptive Behavior Disorders |
| D065886 | Neurodevelopmental Disorders |
| D001523 | Mental Disorders |
| D003147 | Communication Disorders |
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| before magnetoencephalography examination |
| Swanson, Nolan and Pelham | assess the symptoms of attention deficit hyperactivity disorders, 0-78, higher scores mean a worse outcome | before magnetoencephalography examination |
| Wechsler Intelligence Scale for Children | assess the intelligence, 40-160, higher scores mean a better outcome | before magnetoencephalography examination |
| Pediatric Outcome Data Collection Instrument | assess the functional performance, 0-100, higher scores mean a better outcome | before magnetoencephalography examination |
| Child Health Questionnaire- Parent Form | assess the family impact, 0-100, higher scores mean a better outcome | before magnetoencephalography examination |
| Pediatric Quality of Life Inventory | assess the health-related quality of life, 0-100, higher scores mean a better outcome | before magnetoencephalography examination |
| 10 meters walking speed | assess normal and fastest walking speed | before magnetoencephalography examination |
| stairs climbing time | assess ascent and descent stairs time | before magnetoencephalography examination |
| chair-rising time | assess 5 times of chair-rising time | before magnetoencephalography examination |
| timed up and go | assess time for stand up from a chair, go around for 3 meters, and sit down to chair | before magnetoencephalography examination |
| D019954 | Neurobehavioral Manifestations |
| D009461 | Neurologic Manifestations |
| D009422 | Nervous System Diseases |
| D012816 | Signs and Symptoms |
| D013568 | Pathological Conditions, Signs and Symptoms |