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| Name | Class |
|---|---|
| ShanghaiTech University | OTHER |
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The goal of this observational study is to compare the brain functional network between children with autism and typical development, using magnetic resonance imaging (MRI), electroencephalogram/event-related potentials(EEG/ERPs) and functional Near Infrared Spectrum(fNIRs). The main questions it aims to answer are as follows: 1. What are the differences of the functional brain network between autism and TD children? 2. What are the differences of the brain activity in response to special social stimulus between autism and TD children? Participants will receive developmental/intelligence assessments (Griffiths Mental Developmental Scales/Wechsler Preschool and Primary Scale of Intelligence-IV/Wechsler Intelligence Scale for Children-IV for children of different ages), social assessments(Autism Diagnostic Observation Schedule-2nd Edition/Social Communication Questionnaire), EEG/ERPs and fNIRs in resting and task states, and head MRI in natural sleeping state(without sedative).
The cross-sectional observational study will be performed to compare the differences of functional brain network and reactions to social stimulus between children with autism and typical development. The investigators will recruit children aged between 2 to 17 years and 11 months old. They need to receive the mentioned assessments and medical examinations for at least once.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Case group | Subjects in the case group are diagnosed with autism spectrum disorder according to DSM-V and clinical observation. |
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| Control group | Subjects in the control group are healthy children without serious chronic or congenital diseases. |
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| ADOS-2 | Diagnostic Test | The subjects in case group will receive the ADOS-2 assessment to confirm their diagnosis. |
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| Measure | Description | Time Frame |
|---|---|---|
| clinical diagnosis | Clinicians will diagnose subjects as ASD, other neurodevelopmental disorders, or typical developing children, using DSM-5 and ADOS-2. The minimum and maximum scores of ADOS-2 are 0 and 28, and the comparison score of ADOS-2 ranges from 1 to 10, in which higher scores mean a worse outcome. | Baseline (during 2 to 17 years old). |
| Latencies in event related potentials(ERPs) | The investigators will explore the differences of N1/N2, P3/LPP and N400 in event related potentials (ERPs) between case and control groups (children with ASD and typical development) in responses to special prosocial stimulus, and also in false belief tasks. Event related potentials (ERPs) will be tested using eegoâ„¢ mylab of ANT Neuro company. | Baseline (during 2 to 17 years old). |
| Amplitudes in ERPs | Amplitudes of N1/N2, P3/LPP and N400 will be compared between children with autism spectrum disorder and typical development. | Baseline (during 2 to 17 years old). |
| nuclear magnetic resonance imaging(MRI) | Cranial MRI data, including sMRI and fMRI, will be collected during subjects are in natural asleep or awake, using uMR 890 3T of United Imaging company. | Baseline (during 2 to 17 years old). |
| Changes in the concentrations of Oxygenated Hemoglobin (HbO) and deoxygenated Hemoglobin (HbR) during interactions | The investigators will explore inter-group differences of children with ASD and typical development in the concentrations of HbO and HbR during social communication scenes between participants and investigators. | Baseline (during 2 to 17 years old). |
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Case group:
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Exclusion Criteria:
Control group:
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Exclusion Criteria:
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The observation study will be performed in children with ASD and healthy, typically developing children.
| Name | Role | Phone | Extension | |
|---|---|---|---|---|
| Bingrui Zhou | Contact | 13701989113 | zbr1800@163.com |
| Name | Affiliation | Role |
|---|---|---|
| Xiu Xu | Children's Hospital of Fudan University | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Children's Hospital of Fudan University | Recruiting | Shanghai | China |
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| ID | Term |
|---|---|
| D000067877 | Autism Spectrum Disorder |
| D001321 | Autistic Disorder |
| ID | Term |
|---|---|
| D002659 | Child Development Disorders, Pervasive |
| D065886 | Neurodevelopmental Disorders |
| D001523 | Mental Disorders |
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