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Current study try to find out whether social interaction treatment is effective for ASD children. ASD children will be divided into three groups, social interaction treatment group, neuronal cognition treatment and routine treatment group. Based on excited recognition training treatment effect on the core symptom of ADHD by tablet computer, the investigators propose that tablet computer social interaction treatment may induce a significant improvement in ameliorating the social disorder of ASD.
Appropriate and effective treatment coupled with home training can help ASD children restore the ability of language, behavior and learning. However, there is no suitable and effective behavior intervention for home training yet. Current study try a 3 months' randomized double-blinded clinical trial to find out whether tablet computer social interaction treatment at home is effective for ASD children. 90 3-6 years old ASD children will be included and divided into three groups, social interaction treatment group, neuronal cognition treatment and routine treatment group respectively. During the treatment days, children in social interaction treatment group will have 30min social interaction each day for 3 months. Children in neuronal cognition treatment group will experienced neural cognition training 30min each day for 3 months. Children in routine treatment group will keep the same initial treatment. All ASD children are followed up closely. The primary observed indicator is the score of Childhood Autism Rating Scale (CARS) at the inclusion, one month and 3 month after treatment to evaluate the effect of tablet computer social interaction treatment on ASD children.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Social interaction treatment | Active Comparator | During the treatment days, children in social interaction treatment group will have 30min social interaction each day for 3 months. ASD children are followed up closely. |
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| Neuronal cognition treatment | Sham Comparator | Children in neuronal cognition treatment group will experienced neural cognition training 30min each day for 3 months. ASD children are followed up closely. |
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| Routine treatment | Other | Children in routine treatment group will keep the same initial treatment. ASD children are followed up closely. |
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| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Social interaction treatment | Device | Children in social interaction treatment group will have 30min social interaction each day for 3 months. |
|
| Measure | Description | Time Frame |
|---|---|---|
| Childhood Autism Rating Scale, (CARS) | CARS is a behaviour-rating scale used to assess the presence and severity of the symptoms of autism spectrum disorder(ASD), with scores ranging from 15 to 60 and high scores indicating severe symptoms. Change of the CARS from baseline to 3 months after treatment to evaluate the effect of tablet computer social interaction treatment on ASD children. | The baseline and 3 months after treatment |
| Measure | Description | Time Frame |
|---|---|---|
| Social responsiveness scale, (SRS) | SRS is a questionnaire used to assess the presence and severity of social impairment, with high scores indicating severe symptoms. Change of the SRS from baseline to 3 month after treatment to evaluate the effect of computer social interaction treatment on ASD children. | The baseline and 3 months after treatment |
| Measure | Description | Time Frame |
|---|---|---|
| Head magnetic resonance imaging (MRI) | Head MRI is used to detect the structure and function of the brain. Changes in the head MRI results of the subject before and after treatment. | The baseline and 3 months after treatment |
| Head functional Near infra-red spectroscopy (fNIRs) |
Inclusion criteria：
Exclusion criteria：
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| Name | Role | Phone | Extension | |
|---|---|---|---|---|
| Fei Li | Contact | +86-21-25077461 | feili@shsmu.edu.cn |
| Name | Affiliation | Role |
|---|---|---|
| Fei Li | Xinhua Hospital, Shanghai Jiao Tong University School of Medicine | Principal Investigator |
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| Neuronal cognition treatment | Device | Children in neuronal cognition treatment group will experienced neural cognition training 30min each day for 3 months. |
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| Routine treatment | Other | Children in routine treatment group will keep the same initial treatment. |
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| Autism Diagnostic Observation Schedule, ADOS | The ADOS is a structured play session conducted by clinicians, with the total score combines the Social and Communication domain items, with high scores indicating severe symptoms. Change of the ADOS from baseline to 3 months after treatment to evaluate the effect of tablet computer social interaction treatment on ASD children. | The baseline and 3 months after treatment |
| Clinical Global Impression, CGI | CGI is a scale used to assess the severity of the illness and the global improvement of the patient under intervention | The baseline and 3 months after treatment |
Head fNIRs is a non-invasive, non-ionizing method for measuring and imaging the functional hemodynamic response to brain activity. It measures changes in hemoglobin (Hb) concentrations within the brain by means of the characteristic absorption spectra of Hb in the near-infrared range. Changes in the head fNIRs results of the subject before and after treatment. |
| The baseline and 3 months after treatment |